Results 101 to 110 of about 2,651,159 (302)

Biodegradation of polyethylene in digestive gland homogenates of marine invertebrates [PDF]

PeerJ
Вiotic factors may be the driving force of plastic fragmentation along with abiotic factors. Since understanding the processes of biodegradation and biological depolymerization of plastic is important, a new methodological approach was proposed in this ...
Aleksandra Istomina, Victor Chelomin, Andrey Mazur, Avianna Zhukovskaya, Alexander Karpenko, Marina Mazur   +5 more
doaj   +2 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Evolution of the digestive enzymes and bacterial changes of the gastrointestinal tract of the Artemia urmiana during growth period

Invertebrate Survival Journal, 2017
As the digestive enzymes and gastro-intestinal (GI) bacterial community contribute to the health and nutrition of the organism, this study aims to evaluate the ontogeny of bacterial population and digestive enzymes activities in the GI tract of Artemia ...
H Ahmadniaye Motlagh, O Safari, M Farhangi, M Lashkarizadeh-Bami   +3 more
doaj  

Accounting for Digestion Enzyme Bias in Casanovo

Journal of Proteome Research
Abstract A key parameter of any proteomics mass spectrometry experiment is the identity of the enzyme that is used to digest proteins in the sample into peptides. The Casanovo de novo sequencing model was trained using data that was generated with trypsin digestion; consequently ...
Carlo Melendez, Justin Sanders, Melih Yilmaz, Wout Bittremieux, William E. Fondrie, Sewoong Oh, William Stafford Noble   +6 more
openaire   +3 more sources

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

RNA epigenetic modifications in digestive tract cancers: Friends or foes

Pharmacological Research
Digestive tract cancers are among the most common malignancies worldwide and have high incidence and mortality rates. Thus, the discovery of more effective diagnostic and therapeutic targets is urgently required.
Zekai Nian, Ming Deng, Lele Ye, Xinya Tong, Yixi Xu, Yiliu Xu, Ruoyao Chen, Yulin Wang, Feiyang Mao, Chenyv Xu, Ruonan Lu, Yicheng Mao, Hanlu Xu, Xian Shen, Xiangyang Xue, Gangqiang Guo   +15 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

The effect of water temperature on food transit time and digestive enzymes activity in Caspian kutum (Rutilus kutum) larvae

International Journal of Aquatic Biology, 2014
The present study investigates the effects of water temperature on digestive enzymes activity and food transit time in Caspian kutum (Rutilus kutum) larvae.
Nahid Ghysvandi, Abdolmajid Hajimoradloo, Seyed Hossein Hoseinifar   +2 more
doaj