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Regulating Tumor Metabolic Reprogramming with Biomimetic Co‐Delivery of Simvastatin and Kynureninase for Immunotherapy

open access: yesAdvanced Science, EarlyView.
After the intravenous injection of biomimetic and pH/ROS‐responsive PTSK@CRM, the nanoparticles can be accumulated in tumors and release Sim and KYNase to inhibit the tumor growth, regulate the metabolism of cholesterol and Kyn, and reverse the immunosuppressive tumor microenvironment.
Jiaxin Yin   +6 more
wiley   +1 more source
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Conservation of Digestive Enzymes

Physiological Reviews, 2002
The traditional understanding is that an entirely new complement of digestive enzymes is secreted by the pancreas into the small intestines with each meal. This is thought to be necessary because, like food itself, these enzymes are degraded during digestion. In this review we discuss experiments that bring this point of view into question.
Stephen, Rothman   +2 more
openaire   +2 more sources

Human Pancreatic Digestive Enzymes

Digestive Diseases and Sciences, 2007
A primary function of the pancreas is to produce digestive enzymes that are delivered to the small intestine for the hydrolysis of complex nutrients. Much of our understanding of digestive enzymes comes from studies in animals. New technologies and the availability of the sequence of the human genome allow for a critical review of older reports and ...
David C, Whitcomb, Mark E, Lowe
openaire   +2 more sources

Digestive enzymes of some earthworms

Experientia, 1980
4 species of tropical earthworms differed with regard to enzyme activity. The maximum activity of protease and of cellulase occurred in the posterior region of the gut of the earthworms. On the average Octochaetona surensis shows maximum activity and Drawida calebi shows minimum activity for all the enzymes studied.
P C, Mishra, M C, Dash
openaire   +2 more sources

Digestive tract enzymes in phoronida

Comparative Biochemistry and Physiology, 1969
Abstract 1. 1. The digestive tract of Phoronis vancouverensis was examined histochemically for distribution of acid and alkaline phosphatases and esterase, and also by starch-gel electrophoresis. 2. 2. Phosphatases and esterases are found to be restricted to the oesophagus, preventriculus and stomach. 3. 3.
J H, Vandermeulen, R G, Reid
openaire   +2 more sources

Digestive enzymes of cattle

Journal of the Science of Food and Agriculture, 1981
AbstractThe nature of endogenous enzymes in the alimentary tract of cattle is examined and their functions in digestive processes discussed. The main digestive enzymes in cattle are salivary and pancreatic lipase, rennin, pepsin, trypsin, lactase and amylase. Maltase and isomaltase, celliobiase, trehalase, elastase and carboxypeptidase are also present.
openaire   +2 more sources

Enteropancreatic Circulation of Digestive Enzymes

Science, 1975
Intact digestive enzymes can be absorbed by the intestine and resecreted by the pancreas. The pancreas, therefore, appears to be able to recycle proteins much as the liver recycles bile salts, although the magnitude of this process remains uncertain.
C, Leibow, S S, Rothman
openaire   +2 more sources

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