Results 231 to 240 of about 100,617 (251)

Diabetes Mellitus Facilitates Gallstone Formation Through CXCR2‐NETs–Mediated Liver‐Bile Barrier Damage

Advanced Science, EarlyView.
Diabetes is an independent risk factor for gallstones. It upregulates CXCR2 expression in hepatic neutrophils, stimulating the formation of NETs that disrupt hepatocellular tight junctions and the liver‐bile barrier. NETs enter bile to accelerate gallstone development, while sarcosine inhibits CXCR2 and NETs production, effectively reducing diabetes ...
Chao Shi, Shuo Feng, Tianming Liu, Ziang Meng, Yi Zheng, Zhenghao Huang, Tong Wang, Bojian Zhang, Dongbo Xue, Biao Ma, Xianzhi Meng   +10 more
wiley   +1 more source

Clinical Protocols for the Initial Evaluation and Follow-Up of Patients with Chronic Chagas Disease: A Proposal for Referral Centers. [PDF]

Trop Med Infect Dis
Hasslocher-Moreno AM, Rohem ACR, Costa ARD, Sousa AS, Mendes FSNS, Carneiro FM, Mazzoli-Rocha F, Silva GMSD, Veloso HH, Portela LF, Sangenis LHC, Holanda MT, da Silva PS, Saraiva RM, Xavier SS, Mediano MFF.   +15 more
europepmc   +1 more source

Microglial GPR35 Ameliorates Epileptogenesis and Neuroinflammation via PDGFA Domain 2 Signaling

Advanced Science, EarlyView.
Activation of microglial G protein–coupled receptor 35 (GPR35) by L‐kynurenic acid (L‐Kyna) initiates a platelet‐derived growth factor A (PDGFA)–dependent phosphoinositide 3‐kinase–protein kinase B (PI3K–AKT) signaling cascade that dampens hippocampal neuroinflammation, thereby restraining epileptogenesis, lowering seizure susceptibility, and ...
Qi Wang, Tingting Qu, Qibing Sun, Ran Li, Junfei Dong, Yuming Du, Ziyin Xuan, Lei Wang, Hanli Li, Jianyun Sun, Fangliang Chen, Jinshuai Liu, Zifan Yang, Jianxiang Lei, Qian Yang, Bin Wang, Zhiming Zhou, Yu Wang   +17 more
wiley   +1 more source

CRISPR‐Cas9‐Loaded Theranostic Liposomes for Enhancing Radiosensitization of Prostate Cancer through POLD4 Gene Editing under Real‐Time MRI Monitoring

Advanced Science, EarlyView.
This study identifies POLD4 as a potential prostate cancer radiosensitization target through transcriptome sequencing. By encapsulating POLD4‐targeted CRISPR/Cas9 plasmids and USPIONs in cationic liposomes, an MRI‐monitored gene‐editing platform is established.
Xuhui Fan, Ruru Zhang, Linjun Yang, Shixiong Chen, Meijuan He, Yongqiang Wang, Linjie Huang, Jianfeng Zeng, Shuwang Wu, Mingyuan Gao, Han Wang   +10 more
wiley   +1 more source

Functional Bowel Disorders: A Retrospective Descriptive Study in Dakar, Senegal. [PDF]

Cureus
Fall AAA, Gueye MN, Diouf MN, Toure B, Diallo S, Dia D.   +5 more
europepmc   +1 more source

Liver transplantation can prevent the progression of neurological damage in hyperornithinemia-hyperammonemia-homocitrullinuria syndrome and maintain long-term metabolic stability - The largest single-center experience. [PDF]

Orphanet J Rare Dis
Ju H, Wang J, Wang X, Qu W, Zeng Z, Liu Y, Zhang H, Sun LY, Wei L, Zhu ZJ.   +9 more
europepmc   +1 more source

Evaluation and application of electrocardiographic age model for children. [PDF]

Sci Rep
Cao Y, Xu H, Li X, Duan H, Shu Q, Wang W, Li H.   +6 more
europepmc   +1 more source

Zinc and animal health: an in-depth exploration of its role in physiological functions and regulatory molecular mechanisms. [PDF]

J Anim Sci Biotechnol
Cai Z, Wang J, Zhang Y, Li X, Luo J, Gao X, Guo M.   +6 more
europepmc   +1 more source

Acute effect of tetracycline on systemic stress markers and organ histopathology in juvenile Nile tilapia, <i>Oreochromis niloticus</i>. [PDF]

Toxicol Rep
Al-Emran M, Siddique MAUZ, Sheikh MS, Amin MR, Tamanna MR, Puja PK, Rani KB, Hossain AA, Abu Rahad M, Shahjahan M.   +9 more
europepmc   +1 more source

Role of SIRT3 in digestive system diseases and therapeutic prospects (Review). [PDF]

Int J Mol Med
Li J, Liu Q, Yao S, Li X, Zhang L, Wang Y, Wen G, An J, Jin H, Tuo B.   +9 more
europepmc   +1 more source