Results 131 to 140 of about 500,329 (277)

Pathophysiological role of BACH transcription factors in digestive system diseases. [PDF]

Front Physiol, 2023
Song Q, Mao X, Jing M, Fu Y, Yan W.
europepmc   +1 more source

Health Inequality, Education and Medical Innovation [PDF]

Recent studies suggest that health inequalities across socio-economic groups in the US are large and have been growing. We hypothesize that, as in other, non-health contexts, this pattern occurs because more educated people are better able than to take ...
Adriana Lleras-Muney, Sherry Glied
core  

Boron‐Doped Nano‐Crystalline Coated Carbon Fibers for Phasic Dopamine Sensing

Advanced Healthcare Materials, EarlyView.
This uniform coating presents a mix of graphitic and diamond‐like carbon to create a mechanically and electrically robust alternative for the electrochemical detection of dopamine. The electrodes in this work possess the equivalent sensitivity to the state‐of‐the‐art FSCV dopamine detecting electrodes, whilst demonstrating an ability to withstand ...
Simon J. Higham, Juan M. Rojas Cabrera, Youngjong Kwak, Lydia Hong, Andre Chambers, Athavan Nadarajah, Sorel E. De Leon, Young Jun Jung, Negin Jalilinejad, Charles Blaha, Dong Pyo Jang, Yoonbae Oh, Kendall Lee, Alastair Stacey, Shaun L. Cloherty, Michael R. Ibbotson, David J. Garrett, Steven Prawer, Hojin Shin, Wei Tong   +19 more
wiley   +1 more source

EGFR inhibition augments the therapeutic efficacy of the NAT10 inhibitor Remodelin in Colorectal cancer

Journal of Experimental & Clinical Cancer Research
Background Colorectal cancer (CRC) is the second leading cause of cancer-related death worldwide, and treatment options for advanced CRC are limited. The regulatory mechanisms of aberrant NAT10-mediated N4-acetylcytidine (ac4C) modifications in cancer ...
Yongbin Zheng, Dan Song, Ming Guo, Chenhong Wang, Mingzhen Ma, Gongcai Tao, Licui Liu, Xiaobo He, Fengyu Cao, Dan Luo, Qingchuan Zhao, Zhongyuan Xia, Yanxin An   +12 more
doaj   +1 more source

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, EarlyView.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

The pathophyiological role of aminoacyl-tRNA synthetases in digestive system diseases. [PDF]

Front Physiol, 2022
Wusiman W, Zhang Z, Ding Q, Liu M.
europepmc   +1 more source

Simvastatin Restores Uteroplacental Hemodynamics and Trophoblast Function in Obstetric Antiphospholipid Syndrome in a Placenta‐on‐a‐Chip Model

Advanced Healthcare Materials, EarlyView.
Simvastatin mitigates placental hypoperfusion in OAPS by ameliorating abnormal uteromaternal hemodynamics and enhancing trophoblast invasion via optimized endothelial cell interactions under pathological shear stress, as evidenced by results from a placenta‐on‐a‐chip platform.
Hongli Liu, Yuan Wang, Yanjun Cai, Ruixin Guo, Shunhua Liu, Tingting Chen, Tingting Sun, Ruiheng Huo, Tengwei Liu, Qingfeng Lv, Xietong Wang   +10 more
wiley   +1 more source

Diet as a Source of Acrolein: Molecular Basis of Aldehyde Biological Activity in Diabetes and Digestive System Diseases. [PDF]

Int J Mol Sci, 2023
Hikisz P, Jacenik D.
europepmc   +1 more source

Human Brain Vasculature‐on‐a‐Chip Model Constructed With Microvessels Isolated From Cryopreserved Postmortem Human Brain Tissue

Advanced Healthcare Materials, EarlyView.
This manuscript describes the cultivation of viable microvessels from cryopreserved human brain tissue. When embedded in hydrogels and cultured in microfluidic devices, these microvessels exhibit complex architectures reminiscent of arterioles and capillaries, can be perfused, and display intact barrier function. Collectively, these results demonstrate
Brian J. O'Grady, A. Scott McCall, Samuel Cullison, Daniel Chavarria, Matthew S. Schrag, Ethan S. Lippmann   +5 more
wiley   +1 more source

Aquaporins: A new target for traditional Chinese medicine in the treatment of digestive system diseases. [PDF]

Front Pharmacol, 2022
Huang Y, Yan S, Su Z, Xia L, Xie J, Zhang F, Du Z, Hou X, Deng J, Hao E.   +9 more
europepmc   +1 more source