Results 261 to 270 of about 1,671,138 (344)

Selective Lipolysis by Photoactivation of Chaperone‐Mediated Autophagy Using Adipocyte Membrane‐Coated Nanoparticle in Hydrogel

open access: yesAdvanced Materials, EarlyView.
Adipocyte membrane‐coated nanoparticles loaded with rosiglitazone in hydrogel offer an alternative approach to conventional obesity treatments. This system selectively targets adipocytes, inducing lipolysis by activating chaperone‐mediated autophagy through mild photothermal stimulation.
Jaehyun Choi   +8 more
wiley   +1 more source

Development of a Vaginal Extracellular Matrix Hydrogel for Combating Genitourinary Syndrome of Menopause

open access: yesAdvanced Materials, EarlyView.
In this study, a vaginal specific ECM hydrogel (vECM) is developed, optimized for intravaginal topical administration, and evaluated for mitigatation of vaginal atrophy associated with menopause. When applied in a rat model of menopause, vECM improves vaginal epithelial thickness and stem cell phenotype, and despite topical application, vECM also ...
Emma I. Zelus   +6 more
wiley   +1 more source

Granular Hydrogels as Brittle Yield Stress Fluids

open access: yesAdvanced Materials, EarlyView.
This work reports the Kamani‐Donley‐Rogers yield stress fluid model can describe granular hydrogel deformation. The model robustly captures transient rheology and self‐healing behavior for granular gels of varying composition using only six parameters. This framework provides new insight regarding the effect of material parameters on granular yielding ...
Gunnar B. Thompson   +5 more
wiley   +1 more source

Nanoarchitectonics of Metal–Organic Framework and Nanocellulose Composites for Multifunctional Environmental Remediation

open access: yesAdvanced Materials, EarlyView.
Nanoscale metal–organic frameworks (MOFs) and nanocellulose composites have significant potential for the multi‐functional remediation of the environment. This review focused on the synthesis strategies (in situ growth, ex situ growth, and other approaches), typical forms (aerogel, hydrogel, beads, and membrane), and applications in the removal of ...
Ye Song   +13 more
wiley   +1 more source

Volumetric 3D Printing and Melt‐Electrowriting to Fabricate Implantable Reinforced Cardiac Tissue Patches

open access: yesAdvanced Materials, EarlyView.
This study presents an implantable reinforced cardiac patch (RCPatch) combining volumetrically 3D‐printed metamaterials with melt‐electrowritten (MEW) meshes. The design integrates tunable stiff polymer structures with soft, cell‐laden hydrogels. The RCPatch withstands suturing, intraventricular pressure, and cardiac contraction in a large animal ...
Lewis S. Jones   +12 more
wiley   +1 more source

MUTE‐Seq: An Ultrasensitive Method for Detecting Low‐Frequency Mutations in cfDNA With Engineered Advanced‐Fidelity FnCas9

open access: yesAdvanced Materials, EarlyView.
An advanced‐fidelity CRISPR nuclease, FnCas9‐AF2, is rationally engineered to discriminate single‐base mismatches with unprecedented level precision. Integrated into the MUTE‐Seq workflow, FnCas9‐AF2 depletes wild‐type cell‐free DNA, thereby exposing rare tumor‐derived mutant DNA (a molecular “needle in a haystack”).
Sunghyeok Ye   +20 more
wiley   +1 more source

Bioinspired Smart Nanogels for Rapid Blue Laser‐Activated Hemostasis in Gastrointestinal Bleeding

open access: yesAdvanced Materials, EarlyView.
Waxberry‐inspired branched‐silica nanogel can swiftly stop bleeding upon blue laser endoscopy for gastrointestinal hemostasis in the esophagus, stomach, and duodenum of mini‐pigs. Abstract Gastrointestinal bleeding (GIB) is a critical condition that requires rapid and effective intervention.
Ruijue Dan   +12 more
wiley   +1 more source

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