Results 301 to 310 of about 1,671,138 (344)

The bidirectional regulatory network between ATF4 and lncRNAs in systemic diseases. [PDF]

Front Oncol
Wu D, Huang M, Ma C, Xu X, Wu T, Zhang M.   +5 more
europepmc   +1 more source

CRCFound: A Colorectal Cancer CT Image Foundation Model Based on Self‐Supervised Learning

Advanced Science, EarlyView.
CRCFound is a self‐supervised learning‐based CT image foundation model for colorectal cancer (CRC). Pretrained on 5137 unlabeled CRC CT images, it learns universal feature representations, enabling efficient adaptation to various clinical tasks. The model demonstrates outstanding performance and generalization across multiple diagnostic and prognosis ...
Jing Yang, Du Cai, Junwei Liu, Zhenfeng Zhuang, Yibin Zhao, Feng‐ao Wang, Chenghang Li, Chuling Hu, Baowen Gai, Yiping Chen, Yixue Li, Liansheng Wang, Feng Gao, Xiaojian Wu   +13 more
wiley   +1 more source

Exploring AAV‐Mediated Gene Therapy for Inner Ear Diseases: from Preclinical Success to Clinical Potential

Advanced Science, EarlyView.
Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu, Wuhui He, Yun Xiao, Qiong Wu, Qing Zhang, Tiesong Zhang, Lei Xu, Xinyi Pang   +7 more
wiley   +1 more source

Urinary Complement proteome strongly linked to diabetic kidney disease progression. [PDF]

Nat Commun
Md Dom ZI, Moon S, Satake E, Hirohama D, Palmer ND, Lampert H, Ficociello LH, Abedini A, Fernandez K, Liang X, Pickett S, Levinsohn J, O'Neil K, Dillon ST, Mauer M, Galecki AT, Freedman BI, Susztak K, Doria A, Krolewski AS, Niewczas MA.   +20 more
europepmc   +1 more source

NAD+‐Boosters Improve Mitochondria Quality Control In Parkinson's Disease Models Via Mitochondrial UPR

Advanced Science, EarlyView.
Treatment of MPTP‐incubated cells with NAD+‐boosters increase the UPRmt/mitophagy‐related mitochondria quality control (MQC). Disturbed plasma UPRmt‐mitophagy‐mediated MQC profiles in PD patient samples. NMN inhibits motor deficit and forestalls neuropathology phenotypes of PD mice, which is required the atf4‐medicated UPRmt pathway.
Shuoting Zhou, Xi Xiong, Jialong Hou, Qi Duan, Yi Zheng, Tao Jiang, Jiani Huang, Haijun He, Jiaxue Xu, Keke Chen, Wenwen Wang, Jinlai Cai, Jingjing Qian, Huijun Chen, Weihong Song, XinShi Wang, Chenglong Xie   +16 more
wiley   +1 more source

RNF144A and RNF144B: Important molecules for health. [PDF]

Open Life Sci
Jiang W, Liang Y, Han M, He W, Chen K, Deng C, Shen Y.   +6 more
europepmc   +1 more source

Edaravone in Digestive Diseases - A Narrative Review. [PDF]

Drug Des Devel Ther
Lei H, Wang M, Huang M, Fu X.
europepmc   +1 more source

The oncolytic effect of Newcastle disease virus attenuated AMHA1 strain against digestive system tumors

Mohammed A. Hamad, Aous Kahtan Almzaien, Firas R. Jameel, Maeda H. Mohammad, Ahmed Majeed Al-Shammari   +4 more
openalex   +1 more source

Prevalence of pathogens from clinical samples associated with porcine respiratory and digestive diseases in South Korea from 2021 to 2023. [PDF]

Front Vet Sci
Wang HY, Song JK, Shin S, Kim H.
europepmc   +1 more source

Trends in hospital admissions and prescribing due to diseases of the digestive system in England and Wales between 1999 and 2019: An ecological study

Hassan Alwafi, Alaa A. Alsharif
openalex   +1 more source