Results 311 to 320 of about 1,144,886 (364)

Nuclear‐Localized BCKDK Facilitates Homologous Recombination Repair to Support Breast Cancer Progression and Therapy Resistance

Advanced Science, EarlyView.
Under DNA damage, tumor cells rely on efficient DNA repair for survival and therapy resistance. This study has demonstrated that BCKDK localizes to breast cancer cell nuclei, where it binds to and phosphorylates RNF8, thereby blocking ubiquitin‐mediated degradation of RAD51 and enhancing HRR. A selective BCKDK inhibitor synergizes with clinical agents,
Haiying Liu, Jiaqian Feng, Tingting Pan, Pinggen Zhang, Ling Ye, Zetan Jiang, Zilong Zhou, Qiankun Mao, Jian Li, Xinyi Yang, Ping Gao, De Huang, Huafeng Zhang   +12 more
wiley   +1 more source

Causal associations between iron deficiency anemia and digestive system cancers: evidence from a bidirectional two-sample Mendelian randomization study. [PDF]

Discov Oncol
Qin Y, Zhou R.
europepmc   +1 more source

Collaborative Duality of CircGLIS3(2) RNA and Protein in human Wound Repair

Advanced Science, EarlyView.
CircGLIS3(2), a circRNA transiently upregulated in dermal fibroblasts during acute wound healing, is induced by IL‐1α and TGF‐β. Its RNA activates fibroblasts into matrix‐secreting cells, while its encoded protein enhances proliferation. The RNA stabilizes PCOLCE, and the protein interacts with BTF3, collectively accelerating wound repair. Abstract The
Guanglin Niu, Maria A. Toma, Jennifer Geara, Xiaowei Bian, Yongjian Chen, Lihua Luo, Qizhang Wang, Yunting Xiao, Manika Vij, Minna Piipponen, Zhuang Liu, Sho Oasa, Letian Zhang, Dörte Schlesinger, Ákos Végvári, Dongqing Li, Aoxue Wang, Vladana Vukojević, Simon J Elsässer, Pehr Sommar, Ning Xu Landén   +20 more
wiley   +1 more source

Mendelian Randomization Assessment of the Genetic Effects of Lipid-Lowering Drugs on Digestive System Cancers. [PDF]

Food Sci Nutr
Ma K, Wang H, Du Y, Chen T, Yang D, Li Y, Li D.   +6 more
europepmc   +1 more source

Neophytadiene, a Plant Specialized Metabolite, Mediates the Virus‐Vector‐Plant Tripartite Interactions

Advanced Science, EarlyView.
Tomato chlorosis virus (ToCV) infection induces production of neophytadiene, a volatile resulting from chlorophyll degradation that is highly attractive to whiteflies. OBP2, an odorant‐binding protein from insect vector B. tabaci, exhibits a strong binding affinity for neophytadiene.
Xiao‐bin Shi, Hao Yue, Yan Wei, Evan L. Preisser, Pei Wang, Jiao Du, Ji‐xing Xia, Kai‐long Li, Xin Yang, Jian‐bin Chen, Song‐bai Zhang, Zhan‐hong Zhang, Xu‐guo Zhou, De‐yong Zhang, Yong Liu   +14 more
wiley   +1 more source

Direct and indirect burden of COVID-19 on mortality in Spain (2020 to 2022). [PDF]

BMC Public Health
Llorca J, Gómez-Acebo I, Alonso-Molero J, Delgado-Rodríguez M, Dierssen-Sotos T.   +4 more
europepmc   +1 more source

Tongue coating microbiota-based machine learning for diagnosing digestive system tumours. [PDF]

J Oral Microbiol
Ma Y, Jiang Z, Wang Y, Pan L, Liu K, Xia R, Yuan L, Cheng X.   +7 more
europepmc   +1 more source

The oncolytic effect of Newcastle disease virus attenuated AMHA1 strain against digestive system tumors

Mohammed A. Hamad, Aous Kahtan Almzaien, Firas R. Jameel, Maeda H. Mohammad, Ahmed Majeed Al-Shammari   +4 more
openalex   +1 more source

Trends in hospital admissions and prescribing due to diseases of the digestive system in England and Wales between 1999 and 2019: An ecological study

Hassan Alwafi, Alaa Alsharif
openalex   +1 more source

Association between gestational diabetes mellitus and offspring health: a two-sample mendelian randomization study. [PDF]

BMC Pregnancy Childbirth
Yan M, Chen Z, Tang J, Duan X, Peng W, Liu R, Li W, Hu Z, Liu Y.   +8 more
europepmc   +1 more source