Results 41 to 50 of about 506,465 (320)

DNA Checkpoint and Repair Factors Are Nuclear Sensors for Intracellular Organelle Stresses-Inflammations and Cancers Can Have High Genomic Risks. [PDF]

, 2018
Under inflammatory conditions, inflammatory cells release reactive oxygen species (ROS) and reactive nitrogen species (RNS) which cause DNA damage. If not appropriately repaired, DNA damage leads to gene mutations and genomic instability.
Chen, Hongping, Choi, Eric T., Cueto, Ramon, Drosatos, Konstantinos, Fu, Hangfei, Nanayakkara, Gayani K, Park, Joon Y., Qin, Xuebin, Shao, Lijian, Shao, Ying, Sheng, Haitao, Sun, Jianxin, Sun, Yu, Wang, Hong, Wang, Luqiao, Wu, Na, Yang, Qian, Yang, William Y, Yang, Wuping, Yang, Xiaofeng, Zeng, Huihong, Zhu, Qingxian   +21 more
core   +2 more sources

Psychological impact of risk-reducing surgery for gynecologic cancer among women with Lynch syndrome

Gynecologic Oncology Reports
Objective: Prophylactic total hysterectomy and bilateral salpingo-oophorectomy are risk-reducing surgeries (RRS) that can be offered to women with Lynch syndrome (LS) as they reduce the incidence of ovarian and endometrial cancer.
Helen Huband, Kaitlin M McGarragle, Crystal J Hare, Melyssa Aronson, Thomas Ward, Kara Semotiuk, Sarah E Ferguson, Zane Cohen, Tae L Hart   +8 more
doaj   +1 more source

Transduction of Systemically Administered Adeno-Associated Virus in the Colonic Enteric Nervous System and c-Kit Cells of Adult Mice

Frontiers in Neuroanatomy, 2022
Systemic delivery of adeno-associated virus (AAV) vectors transduces the enteric nervous system. However, less is known on the mapping and morphological and neurochemical characterization in the adult mouse colon.
Lixin Wang, Lixin Wang, Pu-Qing Yuan, Pu-Qing Yuan, Collin Challis, Sripriya Ravindra Kumar, Yvette Taché, Yvette Taché   +7 more
doaj   +1 more source

Access to diagnosis and treatment of Chagas disease/infection in endemic and non-endemic countries in the XXI century. [PDF]

, 2007
In this article, Médicos Sin Fronteras (MSF) Spain faces the challenge of selecting, piecing together, and conveying in the clearest possible way, the main lessons learnt over the course of the last seven years in the world of medical care for Chagas ...
Albajar-Vinas, P, Bernal, O, Bulla, D, Morote, S, Villa, L   +4 more
core   +4 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Large-scale survey to estimate the prevalence of disorders for 192 Kennel Club registered breeds [PDF]

, 2017
Background Pedigree or purebred dogs are often stated to have high prevalence of disorders which are commonly assumed to be a consequence of inbreeding and selection for exaggerated features.
Evans, K M, Lewis, T W, Llewellyn-Zaidi, A M, O'Neill, D G, Wiles, B M   +4 more
core   +3 more sources

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Elderly Nutrition Problems. [PDF]

, 2014
In old age people suffer from internal organs diseases very often. More than 90% of the elderly have these diseases. As much as one third of all older people complain of cardiovascular, respiratory and digestive diseases, diseases of the ...
Кравченко, В. С.
core  

Current review of genetically modified lactic acid bacteria for the prevention and treatment of colitis using murine models [PDF]

, 2015
Inflammatory Bowel Diseases (IBD) are disorders of the gastrointestinal tract characterized by recurrent inflammation that requires lifelong treatments.
Azevedo, Vasco, Bermudez Humaran, Luis G., Chatel, Jean Marc, de Moreno, Maria Alejandra, del Carmen, Silvina Andrea, Langella, Philippe, Leblanc, Jean Guy Joseph, Miyoshi, Anderson   +7 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source