Solute carrier transporters: potential targets for digestive system neoplasms [PDF]
Cancer Management and Research, 2018 Jing Xie,1,2 Xiao Yan Zhu,1,2 Lu Ming Liu,1,2 Zhi Qiang Meng1,2 1Department of Integrative Oncology, Fudan University Shanghai Cancer Center, 2Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, People’s Republic of
Xie J, Zhu XY, Liu LM, Meng ZQ
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CircRNAs: a new target for the diagnosis and treatment of digestive system neoplasms [PDF]
Cell Death and Disease, 2021 A circRNA is a type of endogenous noncoding RNA that consists of a closed circular RNA molecule formed by reverse splicing; these RNAs are widely distributed in a variety of biological cells. In contrast to linear RNAs, circRNAs have no 5′ cap or 3′ poly(
Jie Li +7 more
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Eukaryotic initiation factor 5A2 and human digestive system neoplasms. [PDF]
World J Gastrointest Oncol, 2019 Eukaryotic initiation factor 5A2 (eIF5A2), as one of the two isoforms in the family, is reported to be a novel oncogenic protein that is involved in multiple aspects of many types of human cancer. Overexpression or gene amplification of EIF5A2 has been demonstrated in many cancers.
Meng QB +5 more
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CircRNA-Encoded Peptides or Proteins as New Players in Digestive System Neoplasms [PDF]
Frontiers in Oncology, 2022 Circular RNAs (circRNAs) were considered non-coding RNAs. Nowadays, a large number of studies have found that these RNAs contain open reading frames that can be translated in a cap-independent manner, such as internal ribosome entry site (IRES) and N6 ...
Enqing Meng +3 more
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The Role of Intracellular Lipid-Binding Proteins in Digestive System Neoplasms [PDF]
Current OncologyIntracellular lipid-binding proteins (iLBPs) are key mediators of intracellular transport for fatty acids and retinoids, functioning as lipid chaperones.
Christos Kakouratos +3 more
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Systematic Analysis of Molecular Characterization and Clinical Relevance of Liquid–Liquid Phase Separation Regulators in Digestive System Neoplasms [PDF]
Frontiers in Cell and Developmental Biology, 2022 Background: The role of liquid–liquid phase separation (LLPS) in cancer has also attracted more and more attention, which is found to affect transcriptional regulation, maintaining genomic stability and signal transduction, and contribute to the ...
Yaxin Zhang +6 more
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Association Between Anti-bacterial Drug Use and Digestive System Neoplasms: A Systematic Review and Meta-analysis [PDF]
Frontiers in Oncology, 2019 Background: Anti-bacterial drugs are thought to be associated with several malignancies.Objective: We conducted a systematic review and meta-analysis to assess the association between antibacterial drug exposure and the risk of digestive system neoplasms.
Chongxi Bao +3 more
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Efficacy and safety of a novel TKI (anlotinib) for the treatment of advanced digestive system neoplasms: a systematic review and meta-analysis [PDF]
Frontiers in ImmunologyObjectiveTo systematically evaluate the efficacy and safety of anlotinib targeted therapy for the treatment of patients with advanced digestive system neoplasms (DSNs).MethodsClinical trials were extracted from PubMed, the Cochrane Library, Web of ...
Changhui Zhou +3 more
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The Applications of Artificial Intelligence in Digestive System Neoplasms: A Review
Health Data Science, 2023 Importance: Digestive system neoplasms (DSNs) are the leading cause of cancer-related mortality with a 5-year survival rate of less than 20%. Subjective evaluation of medical images including endoscopic images, whole slide images, computed tomography ...
Shuaitong Zhang +11 more
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Mechanisms of Anti-PD Therapy Resistance in Digestive System Neoplasms. [PDF]
Recent Pat Anticancer Drug DiscovDigestive system neoplasms are highly heterogeneous and exhibit complex resistance mechanisms that render anti-programmed cell death protein (PD) therapies poorly effective. The tumor microenvironment (TME) plays a pivotal role in tumor development, apart from supplying energy for tumor proliferation and impeding the body's anti-tumor immune response,
Wu Y +5 more
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