Results 231 to 240 of about 17,458,229 (270)

Ahcy Acts as an Effector of Hnf4a‐Driven Super‐Enhancer Activation to Alleviate MASLD During Intermittent Fasting

Advanced Science, EarlyView.
Our study identifies an Hnf4a‐driven super‐enhancer of hepatic Ahcy that mediates the protective effects of intermittent fasting against MASLD. Disruption of the Ahcy super‐enhancer reduces Ahcy expression and exacerbates lipid accumulation. This pathway prevents aberrant promoter hypermethylation by maintaining the SAM/SAH balance, as exemplified by ...
Huafeng Chen, Shilin Zhang, Xiaojie Deng, Wenqiang Xie, Fen Xu, Jie Shen, Hua Liang   +6 more
wiley   +1 more source

Variation in Attribute Prioritization and Design of Discrete Choice Experiments Across Pharmaceuticals and Medical Devices Patient Preference: A Systematic Review. [PDF]

Patient Prefer Adherence
Jang DH, Park SK, Jung HI, Choi GH, Song HJ, Cho H, Lee S, Park MH, Wilson L, Lee EK.   +9 more
europepmc   +1 more source

[Cancer of the digestive system. III. Early diagnosis of neoplasms of the digestive system].

Gaceta medica de Mexico, 1982
openaire   +1 more source

Adaptation of Echinococcus Multilocularis to Oxidative Stress Depends on EmPDK‐Mediated Metabolic Reprogramming

Advanced Science, EarlyView.
Metabolic adaption presents a vital survival strategy for E. multilocularis. This study identifies EmPDK as a central metabolic regulator governing glucose metabolic reprogramming. Oxidative stress activates EmHIF1α to induce EmPDK expression. Mechanistic characterization reveals this ROS/EmHIF1α/EmPDK axis drives glycolytic reprogramming to sustain ...
Huijuan Wang, Zhijian Xu, Ye Tian, Yao Zhang, Zhe Cheng, Yanhai Wang   +5 more
wiley   +1 more source

Association Between Diabetes Prevalence and Mortality from Gastrointestinal Cancers in Türkiye: A Longitudinal Ecological Study. [PDF]

J Clin Med
Bilici M, Ceylan G, Yılmaz K.
europepmc   +1 more source

35 blood and urine biomarkers and digestive system cancers: A two-sample Mendelian randomization study. [PDF]

Medicine (Baltimore)
Yang C, Xing B, Zhang Z, Jia Y, Peng L.
europepmc   +1 more source

BMI-based metabolic syndrome Z-score and gastrointestinal cancers: A cohort study. [PDF]

Medicine (Baltimore)
Wang W, Liu K, Zhang Y, Li J, Ma C, Wu S, Liu S.   +6 more
europepmc   +1 more source

Body Mass Index and Risks of More Than 40 Cause-Specific Mortality in Chinese Women: A Prospective Cohort Study. [PDF]

J Cachexia Sarcopenia Muscle
Hu J, Ke Y, Yu C, Sun D, Pang Y, Pei P, Yang L, Chen Y, Du H, Chang X, Barnard M, Chen J, Chen Z, Li L, Lv J, China Kadoorie Biobank Collaborative Group.   +15 more
europepmc   +1 more source

Multidimensional Regulatory Network and Spatiotemporal Specificity of FOXO Transcription Factors in Digestive System Tumors: Recent Advances. [PDF]

Int J Mol Sci
Cheng S, Zhang S, Quan J, Jin M.
europepmc   +1 more source