Results 51 to 60 of about 26,948 (252)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Regulation of Digital Assets in the Commonwealth of Australia in the Context of Bankruptcy Estate Formation

RUDN Journal of Law
The article examines the legal regulation of digital assets in Australia, with particular emphasis on their status within bankruptcy procedures. The study’s relevance stems from rapid technological advncements, the surging popularity of digital assets ...
Stanislav V. Odintsov, Maria S. Gribanowskaya   +1 more
doaj   +1 more source

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane, Valentina Giunchiglia, Michael C. B. David, Magdalena A. Kolanko, William R. Trender, Peter J. Hellyer, Harmeena Kaur, David J. Sharp, Christopher Carswell, Paresh A. Malhotra, Adam Hampshire   +10 more
wiley   +1 more source

“CATCH ME IF YOU CAN!” – LEGAL STATUS OF DIGITAL ASSETS IN BANKRUPTCY PROCEEDINGS IN THE REPUBLIC OF SERBIA

Pravo
The very emergence of digital assets represents a revolutionary phenomenon in technology, economics, and law. Their regulation introduces into the legal system a new institute of property law, whereby digital assets, alongside things, rights, and ...
Đuro Đurić, Vladimir Jovanović
doaj   +1 more source

Incentives for Crypto-Collateralized Digital Assets

Proceedings, 2019
Digital currencies such as Bitcoin frequently suffer from high price volatility, limiting their utility as a means of purchasing power. Hence, a popular topic among cryptocurrency researchers is a digital currency design which inherits the ...
Philip N. Brown
doaj   +1 more source

Natural Frequencies of Levodopa‐Induced Dyskinesia in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Abnormal involuntary movements, known as dyskinesias, are common complications of levodopa treatment in patients with Parkinson's disease and can significantly impair quality of life. The underlying pathophysiology remains unclear, and current therapeutic options are limited.
Ioannis U. Isaias, Federica Avantaggiato, Gianni Pezzoli, Andrea Canessa   +3 more
wiley   +1 more source

Developing Criteria for Valuing Digital Assets and Evaluation of Axes Identified Based on Mutual Matrices [PDF]

مطالعات تجربی حسابداری مالی
The purpose of this research is to develop a framework for digital asset accounting and to evaluate the axes identified based on mutual matrices. The methodology of this study is exploratory and developmental, combining qualitative and quantitative data ...
Tayebeh Gharibi, Neamat Rostami Mazouei, Azar Moslemi, Masoud Taherinia   +3 more
doaj   +1 more source

Misuse of Digital Assets: Current Legislation, Challenges and Recommendations

Collection Regional Law Review, 2023
In 2020, the Republic of Serbia adopted the Law on Digital Assets (Official Gazette of the Republic of Serbia no. 153/2020). Legal regulation of the issuance, use and circulation of digital assets is present in a very small number of European countries ...
Jelena Kostić
doaj   +1 more source

Posterior Disconnection Syndrome in Early‐Stage Adult‐Onset Cerebral Adrenoleukodystrophy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Adult‐onset cerebral adrenoleukodystrophy is potentially treatable but often difficult to recognize before advanced cerebral involvement. Herein, we describe three men with early‐stage disease who initially presented with subtle visual complaints rather than subcortical dementia. Targeted neuropsychological testing revealed higher‐order visual
Kazuto Katsuse, Takashi Matsukawa, Yumiko Nakamura, Kazuo Kakinuma, Shoko Ota, Ryo Hara, Saki Nakashima, Kaoru Ito, Yutaro Nakamori, Toshiyuki Kakumoto, Masashi Hamada, Shigenori Kanno, Kyoko Suzuki, Tatsushi Toda   +13 more
wiley   +1 more source