Results 71 to 80 of about 5,379,261 (318)

Optimisation of robust singleplex and multiplex droplet digital PCR assays for high confidence mutation detection in circulating tumour DNA

Scientific Reports, 2019
Liquid biopsies offer the potential to monitor cancer response and resistance to therapeutics in near real-time. However, the plasma cell free DNA (cfDNA) level can be low and the fraction of circulating tumour DNA (ctDNA) bearing a mutation – lower ...
V. Rowlands, Andrzej J. Rutkowski, Elena Meuser, T. Hedley Carr, Elizabeth A. Harrington, J. Barrett   +5 more
semanticscholar   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Addressing the cyber safety challenge: from risk to resilience [PDF]

, 2014
Addressing the cyber safety challenge: from risk to resilience describes the cyber safety issues emerging from a range of technology trends, how different populations are using technologies and the risks they face, and how we can effectively respond
Amanda Third, Anne Collier, Pota Forrest-Lawrence   +2 more
core  

Alignment of galaxy spins in the vicinity of voids

, 2009
We provide limits on the alignment of galaxy orientations with the direction to the void center for galaxies lying near the edges of voids. We locate spherical voids in volume limited samples of galaxies from the Sloan Digital Sky Survey using the HB ...
A. Faltenbacher ., A. Heavens, A. Slosar ., A.G. Doroshkevich, Anže Slosar, B.S. Ryden, D. Paz, F.C. van den Bosch, I. Trujillo, J. Bailin, J. Lee, J. Lee, J. Lee, J. Lee, L. Hui, M.J. Rees, Martin White, O. Hahn, P. Catelan, P. Schneider, S.D.M. White, S.M. Fall, SDSS collaboration, SDSS collaboration, SDSS collaboration, U. Pen, W. Hu   +26 more
core   +1 more source

A Method of Justifying Confidence in the Safety of Digital Health Interventions [PDF]

, 2020
Digital health interventions (DHIs) enable improvements in health strategy and address health system challenges. The World Health Organization provides a formal classification for DHIs. However, safety claims, about such interventions, vary in quality and are often vague as to how they are communicated between technical, clinical experts and ...
Harrison, Stuart, Despotou, George, Arvanitis, Theodoros N.   +2 more
openaire   +2 more sources

Digital Outing Confidence as a Mediator in the Digital Behavior Regulation and Internet Content Awareness Relationship

, 2020
The public digital outing refers to people creating and sharing personal information over the social media platforms. This specific digital outing behaviour is none of the less uniquely vulnerable to the negative effects of the digital public, triggering
Dana Rad, Daniel Dixon, Gavril Rad
semanticscholar   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Improved Cosmological Constraints from Gravitational Lens Statistics

, 2004
We combine the Cosmic Lens All-Sky Survey (CLASS) with new Sloan Digital Sky Survey (SDSS) data on the local velocity dispersion distribution function of E/S0 galaxies, $\phi(\sigma)$, to derive lens statistics constraints on $\Omega_\Lambda$ and ...
Browne I. W. A., Charles R. Keeton, Cole S., Fukugita M., Fukugita M., Jonathan L. Mitchell, Joshua A. Frieman, Kauffmann G., Kauffmann G., Lacey C., Mao S. D., Narayan R., Patnaik A. R., Patnaik A. R., Patnaik A. R., Prugniel P., Quast R., Ravi K. Sheth   +17 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Mass media impact on opinion evolution in biased digital environments: a bounded confidence model

Scientific Reports, 2023
People increasingly shape their opinions by accessing and discussing content shared on social networking websites. These platforms contain a mixture of other users’ shared opinions and content from mainstream media sources.
Valentina Pansanella, Alina Sîrbu, Janos Kertesz, Giulio Rossetti   +3 more
doaj   +1 more source