Results 71 to 80 of about 1,712,948 (298)
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Manuscriptorium Digital Library and ENRICH Project: Means for Dealing with Digital Codicology and Palaeography [PDF]
, 2009 Codicology and palaeography in the digital age can be developed both through adapting existing methods and using information and communication technologies.
Knoll, Adolf, Uhlíř, Zdeněk
core
Digital lattice gauge theories
, 2017 We propose a general scheme for a digital construction of lattice gauge theories with dynamical fermions. In this method, the four-body interactions arising in models with $2+1$ dimensions and higher, are obtained stroboscopically, through a sequence of ...
Cirac, J. Ignacio +3 more
core +1 more source
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin +3 more
wiley +1 more source
Digital Technologies in Construction
Scientific journal “ACADEMIA. ARCHITECTURE AND CONSTRUCTION”, 2018 The article is devoted to the analysis of the current state and prospects of development of digital technologies in construction. The fundamental concepts of digital economy, digital production and digital technologies are introduced; a peculiar "evolution" of the design process in construction is described (transition from so-called "paper-based ...
openaire +3 more sources
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
BuildingsTo effectively combat environmental challenges, it is necessary to evaluate urban residential building carbon emissions and implement energy-efficient, emission-reducing strategies.
Jian Xu +5 more
doaj +1 more source
Building Information Modelling (BIM) and the Internet-of-Things (IoT): A Systematic Mapping Study
IEEE Access, 2020 Of recent, Building Information Modelling (BIM) has become an influential paradigm for the development of better project delivery practices to improve construction and operational efficiencies.
Baydaa Hashim Mohammed +3 more
doaj +1 more source