Results 41 to 50 of about 1,164,910 (302)

Musical preferences and technologies: Contemporary material and symbolic distinctions criticised [PDF]

, 2015
Today how individuals interact with various cultural items is not perfectly consistent with theoretical frameworks of influential scholars on cultural consumption, such as Bourdieu (1984), Gans (1999), and Peterson and Simkus (1992).
Adrian Leguina, Bull M, Crisell A, French-Davis R, Frith S, Gans HJ, Gayo M, Gonzalez JP, Karmy E, Lebaron F, Paul Widdop, Peterson RA, Pinch T, R Core Team, Sara Arancibia-Carvajal, Van Dijk JAGM, Warde A   +16 more
core   +3 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

I care for my child: parental mediation of children’s digital consumption in India

Cogent Social Sciences
The fast-advancing digital scenario has facilitated the prolific use of digital platforms and applications on a gamut of devices, including smartphones, tablets, laptops, smartwatches and smart televisions. Against the backdrop of high screen consumption
Sudha Venkataswamy
doaj   +1 more source

The impact of digital economy on consumption and education industry: Taking China as an example [PDF]

SHS Web of Conferences
Looking around the world, a new round of scientific and technological revolution and industrial transformation is developing in depth. The digital economy has become an important factor affecting global resource allocation, industrial structure, and the ...
Chen Huiyu
doaj   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

A low-power reconfigurable ADC for biomedical sensor interfaces [PDF]

, 2009
This paper presents a 12-bit low-voltage low-power reconfigurable Analog-to-Digital Converter (ADC). The design employs Switched Capacitor (SC) techniques and implements a Successive Approximation (SA) algorithm.
Delgado Restituto, Manuel, Medeiro Hidalgo, Fernando, Rodríguez Pérez, Alberto, Rodríguez Vázquez, Ángel Benito   +3 more
core   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

14-bit 2.2-MS/s sigma-delta ADC's [PDF]

, 2000
This paper presents the design and test results of a fourth-order and sixth-order 14-bit 2.2-MS/s sigma-delta analog-to-digital converter (ADC). The analog modulator and digital decimator sections were implemented in a 0.35 μm CMOS double-poly triple ...
Geddie, C et al, Hoke, M, Kocak, T, Morizio, J   +3 more
core   +2 more sources

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source