Results 81 to 90 of about 1,164,910 (302)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan   +9 more
wiley   +1 more source

The digital-only media consumer: Key findings from a conversation with all-digital millenials [PDF]

open access: yes
This study offers insight on the digital-onlys, a sub-population of Millennials who only consume media through digital platforms. Based on informal group conversations with 16 to 34 year-olds, the study provides a snapshot of their daily media ...
Danielle Desjardins
core  

High‐Resolution MRI Revealed Different Etiology‐Specific Associations With Cerebral Infarction in Adult Moyamoya Vasculopathy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐resolution MRI enables detailed assessment of intracranial vessel wall pathology in moyamoya vasculopathy. We aimed to classify adult moyamoya vasculopathy etiologies using high‐resolution MRI and to examine subtype‐specific associations between high‐resolution MRI features and ischemic infarction.
Guangsong Han   +8 more
wiley   +1 more source

Clinical Practice Guideline for Evaluation and Management of Peripheral Nervous System Manifestations in Sjögren's Disease

open access: yesArthritis Care &Research, EarlyView.
Objective Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies.
Anahita Deboo   +88 more
wiley   +1 more source

The impact of digital consumption on energy transition in China

open access: yesCogent Economics & Finance
Against the backdrop of a flourishing digital economy, digital consumption has emerged as a crucial driving force behind the expansion of domestic demand, overcoming of spatial and temporal limitations, and enhancement of the efficiency of resource ...
Yan Su, Wanjun Zheng, Ping Yu
doaj   +1 more source

New business and economic models in the connected digital economy [PDF]

open access: yes, 2013
This paper discusses business models as a systemic phenomenon as opposed to traditional reductionistic approaches of business disciplines. It presents the ways connectivity change economic models due to the availability of consumption data as an economic
Ng, Irene C. L.
core   +1 more source

Building a Framework for Sexual and Reproductive Health Care in the Rheumatology Context: Content and Approaches

open access: yesArthritis Care &Research, EarlyView.
People with systemic autoimmune and rheumatic diseases (SARDs) are at higher risk than the general population of experiencing adverse pregnancy and perinatal outcomes such as preeclampsia, intrauterine growth restriction, and maternal and/or fetal death.
Mehret Birru Talabi, Sonya Borrero
wiley   +1 more source

Digitalisation of Consumption and Digital Humanities

open access: yesDigital Humanities in the Nordic and Baltic Countries Publications, 2018
Digitalisation transforms practically all areas of the modern life: everything that can, will be digitalised. Especially the everyday routines and consumption practices are under continual change.
Toni Ryynänen, Torsti Hyyryläinen
doaj   +1 more source

Characteristics and Outcomes of Male Participants in a Multicenter Longitudinal Australian Study Cohort

open access: yesArthritis Care &Research, EarlyView.
Objective The aim of this study was to determine the differences in demographic, serologic, and clinical characteristics between male and female patients with systemic sclerosis (SSc) in an Australian cohort. Methods This was a retrospective observational study using data from the Australian Scleroderma Cohort Study.
Emily Lin   +14 more
wiley   +1 more source

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