Results 41 to 50 of about 41,406,751 (291)

Core Competencies for Maritime Business Educators in the Digital Era

Frontiers in Psychology, 2022
In light of digitalization, the objectives of this study are to (1) identify the emerging, core competencies of maritime business educators (MBE) and (2) examine their effects on perceived teaching performance. A systematic review of the contemporary literature was first performed to build a competency framework.
Yuen, Kum Fai, Tan, Lovevin, Loh, Hui Shan   +2 more
openaire   +4 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Modular Supervisory Control for the Coordination of a Manufacturing Cell with Observable Faults

Sensors, 2022
In the present paper, a manufacturing cell in the presence of faults, coming from the devices of the process, is considered. The modular modeling of the subsystems of the cell is accomplished using of appropriate finite deterministic automata.
Nikolaos D. Kouvakas, Fotis N. Koumboulis, Dimitrios G. Fragkoulis, Aristotelis Souliotis   +3 more
doaj   +1 more source

Evolution at the Core of Digital Twin Engineering

2025 ACM/IEEE 28th International Conference on Model Driven Engineering Languages and Systems Companion (MODELS-C)
Presented at the 2nd Int. Conf. on Engineering Digital Twins (EDTconf'25)
Alskaif, Tarek, Babur, Önder, Bordeleau, Francis, Cleophas, Loek, Combemale, Benoit, Denil, Joachim, Haugen, Øystein, Michael, Judith, Nguyen, Phu, Seceleanu, Tiberiu, van den Brand, Mark, Vangheluwe, Hans   +11 more
openaire   +4 more sources

Element 2 Chairs and Course List Core General Education Assessment, 2019-2020

, 2020
The Chairs and Course List for Element 2 - Mathematics as part of the institution’s ongoing general education Core assessment ...
Undergraduate Core Oversight Committee, Wright State University
core   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Element 2 Assessment Report Template Core General Education Assessment, 2019-2020

, 2020
The Assessment Report Template for Element 2 - Mathematics as part of the institution’s ongoing general education Core assessment ...
Undergraduate Core Oversight Committee, Wright State University
core   +1 more source

Soft Sensor Design via Switching Observers

Sensors, 2023
The goal of the paper is the design of soft sensors for single input single output (SISO) nonlinear processes. This goal is of essential importance for process monitoring, fault detection and fault isolation.
Fotis N. Koumboulis, Dimitrios G. Fragkoulis, Nikolaos D. Kouvakas, Aikaterini Feidopiasti   +3 more
doaj   +1 more source