Results 81 to 90 of about 3,055,735 (327)
Dynamic Connectedness of Major Digital Currencies: A Time-Varying Approach
Discrete Dynamics in Nature and Society, 2022 The continuous increase in the market capitalization of digital currencies has determined them to be an essential force driving global financial development. Research on digital currency connectedness has implications for the pricing of related financial
Ran Tao, Shuyao Qi
doaj +1 more source
Do consumers need a ‘Bit’ more protection under Australian consumer laws? The regulatory risks and challenges of Bitcoin [PDF]
, 2018 The creation of Bitcoin, as a digital currency, has been a significant development in the world of finance, in that it provides an alternative method of payment to consumers and businesses who use Bitcoin as a means to buy or sell goods or simply as an ...
Van Der Westhuizen, Chinelle
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Tehnologia blockchain, monedele virtuale și dreptul penal [PDF]
Penalmente Relevant, 2021 In this article, the author primarily aims to clarify from a technical and terminological point of view several notions relevant for the blockchain ecosystem.
George Zlati
doaj
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
The risks resulting from crypto-currencies trade expansion
المجلة الدولية للأداء الاقتصادي, 2023 This study aims at demonstrating the negative effects resulting from crypto currencies trade. These currencies differ from the traditional ones in terms of being intangible and decentralized, using these currencies increase through the internet, because ...
Nadia LOUZRI
doaj
Cryptocurrency: History, Advantages, Disadvantages, and the Future [PDF]
, 2019 Cryptocurrency is a digital asset that has seen a large amount of attention within the past five years. Its origin is intriguing to some based upon its newness, yet it has invoked mysticism and skepticism in others.
Rice, Mitchell
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Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source