Results 191 to 200 of about 11,276 (236)

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

An Efficient Biological Codon Recognition Reservoir Computing System Based on Low‐Energy Epitaxial Hf0.52Zr0.48O2 Ferroelectric Memristors

Advanced Science, EarlyView.
This work reports on epitaxially grown Hf0.52Zr0.48O2 ferroelectric memristors with high stability (high durability exceeding 108 cycles and a retention time exceeding 104 s for 16 states) and ultra‐low operating energy consumption (∼121 fJ). A memristor array‐based reservoir computing system is constructed and applied for the first time in the field ...
Ying Liu, Jikang Xu, Yongqing Jia, Wenxuan Wang, Weifeng Zhang, Biao Yang, Xiaobing Yan   +6 more
wiley   +1 more source

Insights from initial experience for nasopharyngeal carcinoma patients treated with proton therapy. [PDF]

Tech Innov Patient Support Radiat Oncol
Sin SY, Chen SN, Soong YL, Tan HQ.
europepmc   +1 more source

Protocol to isolate and co-culture primary mouse hepatocytes, hepatic stellate cells, and Kupffer cells under physiological conditions. [PDF]

STAR Protoc
Ballester Martinez M, Filomeni G, Rizza S.   +2 more
europepmc   +1 more source

Influence of Cushion Plant <i>Androsace tapete</i> on Nitrogen Uptake Strategies of Associated Alpine Plants. [PDF]

Plants (Basel)
Xing S, He YT, Shi PL, Xu XL.
europepmc   +1 more source

Human-relevant transcranial magnetic stimulation in awake rhesus macaques assisted by a non-invasive head and arm fixation apparatus. [PDF]

iScience
Padányi A, Knakker B, Kiefer E, Lendvai B, Hernádi I.   +4 more
europepmc   +1 more source

One landscape does not fit all: Diverse arthropod responses to land use. [PDF]

Ecol Appl
Lippey MK, Rosenheim JA, Paredes D, Karp DS, Emery SE, Chaplin-Kramer R, Sharp R, Meineke EK.   +7 more
europepmc   +1 more source