Results 61 to 70 of about 58,497,499 (306)

Glaucoma Identification Using Convolutional Neural Networks Ensemble for Optic Disc and Cup Segmentation

IEEE Access
Glaucoma is one of the diseases that can cause incurable blindness. The first noticeable symptoms appear only when the disease has progressed but an early diagnosis of the disease prevents the severe consequences of disease progression. In this paper, we
Sandra Virbukaite, Jolita Bernataviciene, Daiva Imbrasiene   +2 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

ATCodeR: a dictionary-based R-tool to standardize medication free-text

Scientific Reports
Over the past decades, oncology treatment paradigms have developed significantly. Yet, the often unstructured nature of substance-related documentation in medical records presents a time-consuming challenge for analyzing treatment patterns and outcomes ...
Isabel Schnorr, Stefanie Andreas, Linnea Schumann, Svenja Hahn, Jörg Janne Vehreschild, Daniel Maier   +5 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Responsible AI innovation in the public sector: Lessons from and recommendations for facilitating Fundamental Rights and Algorithms Impact Assessments

Journal of Responsible Technology
Since the initial development of the Fundamental Rights and Algorithms Impact Assessment (FRAIA) in 2021, there has been an increasing interest from public sector organizations to gain experience with performing a FRAIA in contexts of developing ...
I.M. Muis, J. Straatman, B.A. Kamphorst
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Reviewing the lines of therapy-concept in cancer treatment: a survey study among physicians

BMC Cancer
Background While the line of therapy (LOT) concept is crucial for clinical decision-making in oncology, the concept lacks a consensual understanding bearing the risk of miscommunication. This study examines physicians’ understanding of LOT, its perceived
Lisa M. M. Falchetto, Bernd Bender, Ian Erhard, Stefanie Andreas, Linnea L. I. Schumann, Isabel Schnorr, Karin Berger-Thürmel, Jörg Janne Vehreschild, Daniel Maier   +8 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Proteogenomic network analysis reveals dysregulated mechanisms and potential mediators in Parkinson’s disease

Nature Communications
Parkinson’s disease is highly heterogeneous across disease symptoms, clinical manifestations and progression trajectories, hampering the identification of therapeutic targets.
Abolfazl Doostparast Torshizi, Dongnhu T. Truong, Liping Hou, Bart Smets, Christopher D. Whelan, Shuwei Li   +5 more
doaj   +1 more source

Exploring Multidimensional Embeddings for Decision Support Using Advanced Visualization Techniques

Informatics
As artificial intelligence has evolved, deep learning models have become important in extracting and interpreting complex patterns from raw multidimensional data.
Olga Kurasova, Arnoldas Budžys, Viktor Medvedev   +2 more
doaj   +1 more source