Results 141 to 150 of about 134,422 (303)

Development and Evaluation of a Web-Based Platform for Personalized Educational and Professional Assistance for Dementia Caregivers: Proposal for a Mixed Methods Study

JMIR Research Protocols
BackgroundAlzheimer disease (AD) and AD-related dementia are prevalent concerns for aging populations. With a growing older adult population living in the United States, the number of people living with dementia is expected to ...
Logan DuBose, Qiping Fan, Louis Fisher, Minh-Nguyet Hoang, Diana Salha, Shinduk Lee, Marcia G Ory, Tokunbo Falohun   +7 more
doaj   +1 more source

Modulation of Non‐Rhythmic Temporal Prediction by Subthalamic Nucleus Deep Brain Stimulation (STN‐DBS) in Parkinson's Disease

Movement Disorders, EarlyView.
Background Accurate temporal prediction, essential for adaptive motor behavior, relies on corticobasal ganglia circuits. In Parkinson's disease (PD), both motor and non‐motor functions are impaired. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) effectively alleviates motor symptoms, but its effects on non‐motor domains, like temporal ...
Rebecca Burke, Marleen J. Schoenfeld, Christian K.E. Moll, Alessandro Gulberti, Monika Pötter‐Nerger, Andreas K. Engel   +5 more
wiley   +1 more source

Early Autonomic Burden in Prodromal Parkinson's Disease Predicts Cognitive Impairment

Movement Disorders, EarlyView.
Abstract Background Autonomic dysfunction is a known contributor to cognitive impairment in Parkinson's disease (PD), but its impact during prodromal stage is unknown. Objective The aim was to determine whether early autonomic burden predicts incident cognitive impairment in prodromal PD.
A. Enrique Martinez‐Nunez, Kelly A. Mills, Joseph Seemiller, Christopher B. Morrow, Gregory M. Pontone, Abhimanyu Mahajan   +5 more
wiley   +1 more source

Pleiotropic effects of variants in dementia genes in Parkinson disease [PDF]

, 2018
Benitez, Bruno A, Budde, John, Cooper, Breanna, Cruchaga, Carlos, David, Albert A, Diez-Fairen, Monica, Dube, Umber, Fernandez, Maria V, Ibanez, Laura, Ortega-Cubero, Sara, Pastor, Pau, Perlmutter, Joel S   +11 more
core   +2 more sources

Imaging Studies of Aging, Neurodegenerative Disease, and Alcoholism. [PDF]

, 1995
Neurodegenerative diseases such as Alzheimers disease, disorders such as alcoholism, and the aging process can lead to impaired cognitive function and dementia.
Eberling, Jamie, JAGUST, William J
core  

Quantitative Analysis of Locus Coeruleus Neurons and Thalamic Noradrenergic Axons in a Progressive 1‐Methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine Monkey Model of Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Parkinson's disease is mainly characterized by dopaminergic neurodegeneration in the substantia nigra pars compacta (SNc) and α‐synuclein accumulation. The locus coeruleus (LC) is also affected in Parkinson's disease and linked to some nonmotor symptoms, but the extent and timing of its degeneration remain unclear.
Megan Carrillo, Nagore Hernández‐Pinedo, Josefa Zaldivar‐Diez, Isabel Pérez‐Santos, José A. Obeso, Carmen Cavada, Javier Blesa   +6 more
wiley   +1 more source

Digital life storybooks for people with dementia living in care homes: an evaluation

Clinical Interventions in Aging, 2016
Ponnusamy Subramaniam,1 Bob Woods2 1Health Psychology Programme, University Kebangsaan Malaysia, Kuala Lumpur, Malaysia; 2Dementia Services Development Centre Wales, Bangor University, Bangor, Gwynedd, UK Background and aim: There is increasing ...
Subramaniam P, Woods B
doaj  

The COMFORTage project: study protocol for the integration of multiple sources towards personalised preventions at Ace Alzheimer Center Barcelona

Frontiers in Digital Health
IntroductionAgeing is accompanied by gradual biological and cognitive changes that increase vulnerability to chronic diseases and neurodegenerative conditions.
Sergi Valero, Sergi Valero, Andrea Miguel, Josep Blazquez-Folch, Berta Calm, Montserrat Alegret, Montserrat Alegret, Ariadna Solivar, George Manias, Athos Antoniades, Nelina Angelova, Despina Psimaris, Sofia Segkouli, Amèrica Morera, Natalia Tantinya, Maitee Rosende-Roca, Amanda Cano, Maria Victoria Fernández, Pilar Sanz-Cartagena, Miren Jone Gurruchaga, Lluís Tárraga, Lluís Tárraga, Mercè Boada, Mercè Boada, Agustín Ruiz, Agustín Ruiz, Agustín Ruiz, Agustín Ruiz, Marta Marquié, Marta Marquié, and COMFORTage Consortium   +30 more
doaj   +1 more source

In Vivo Mapping of Catecholaminergic Loss and Iron Deposition in Huntington's Disease

Movement Disorders, EarlyView.
Abstract Background The pathophysiology of Huntington's disease (HD) remains obscure. Magnetic resonance imaging (MRI) can reveal in vivo molecular changes related to disease pathology. Objectives To investigate catecholaminergic neuronal integrity and subcortical brain iron accumulation in HD employing neuromelanin‐sensitive MRI, and quantitative ...
Edoardo R. de Natale, Heather Wilson, Efstratios Karavasilis, Athanasia Liozidou, Chrisoula Kartanou, Georgios Velonakis, Jens Kuhle, Ioannis Zalonis, Georgia Karadima, Leonidas Stefanis, Georgios Koutsis, Marios Politis   +11 more
wiley   +1 more source

Use of Digital Biomarkers from Sensing Technologies to Explore the Relationship Between Daytime Activity Levels and Sleep Quality in Nursing Home Residents with Dementia: A Proof-of-Concept Study

Sensors
Inactivity and increases in psychological and behavioral symptoms are common for people with dementia, and current assessment relies on proxy-rated tools.
Lydia D. Boyle, Monica Patrascu, Bettina S. Husebo, Ole Martin Steihaug, Kristoffer Haugarvoll, Brice Marty   +5 more
doaj   +1 more source