Results 71 to 80 of about 134,422 (303)

Amyloid β Instigates Cardiac Neurotrophic Signaling Impairment, Driving Alzheimer's Associated Heart Disease

Advanced Science, EarlyView.
This research identified cardiac amyloid pathology, neurotrophic factor depletion, and reduced myocardial nerve function in a transgenic model of cerebral amyloidosis (Tg2576), Aβ‐challenged cardiomyocytes, and in human AD heart tissue. These findings carry significant diagnostic and therapeutic implications, emphasizing the role of neuro‐signaling ...
Andrea Elia, Rebecca Parodi‐Rullan, Rafael Vazquez‐Torres, Ashley Carey, Huaqing Zhao, Sabzali Javadov, Silvia Fossati   +6 more
wiley   +1 more source

Connectivity changes in two-channel prefrontal ERP associated with early cognitive decline in the elderly population: beta band responses to the auditory oddball stimuli

Frontiers in Aging Neuroscience
BackgroundThis study utilized recent advancements in electroencephalography (EEG) technology that enable the measurement of prefrontal event-related potentials (ERPs) to facilitate the early detection of mild cognitive impairment (MCI).
Jang-Han Bae, Jang-Han Bae, Minho Choi, Jang Jae Lee, Kun Ho Lee, Kun Ho Lee, Kun Ho Lee, Jaeuk U. Kim, Jaeuk U. Kim   +8 more
doaj   +1 more source

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

Advanced Science, EarlyView.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao, Juan Ignacio Jiménez‐Loygorri, Yunguang Qiu, You Jung Kang, Khanh Van Do, Annabel E. Smith, Junjie Huang, Jun‐ping Pan, Lipeng Mao, Ang Li, Hangge Yang, Yahyah Aman, Maria Jose Donate Lagartos, Sofie Hindkjær Lautrup, Anbin Chen, Kristina Xiao Liang, Hailong Zhang, Juan Yi, Xurui Jin, Tin Cho Cheung, Olympia Apokotou, Florentia Papastefanaki, Rebecca Matsas, William A. McEwan, Feixiong Cheng, Hansang Cho, Guobing Chen, Huanxing Su, Konstantinos Palikaras, Oscar Junhong Luo, Qian Hua Zhao, Ding Ding, Cornelia van Duijn, Nektarios Tavernarakis, Patricia Boya, Tewin Tencomnao, Evandro F. Fang   +36 more
wiley   +1 more source

The use of a digital life story to support person-centred care of older adults with dementia: A scoping review

Digital Health
Introduction A life story (LS) is a tool healthcare professionals (HCPs) use to help older adults with dementia preserve their identities by sharing their stories. Applied health technology can be considered a niche within welfare technology.
Helén Dellkvist, Ana Luiza Dallora, Line Christiansen, Lisa Skär   +3 more
doaj   +1 more source

System development guidelines from a review of motion-based technology for people with MCI or dementia [PDF]

, 2018
As the population ages and the number of people living with dementia or mild cognitive impairment (MCI) continues to increase, it is critical to identify creative and innovative ways to support and improve their quality of life.
Aarhus, Astell, Astell, Bamidis, Ben-Sadoun, Benveniste, Billis, Bouchard, Brox, Chang, Cutler, Cutler, Czarnuch, Czarnuch, Czarnuch, de Werd, Dove, Dove, Dove, Fenney, Gerling, Gerling, González-Palau, Higgins, Hughes, Konstantinidis, Leahey, Legouverneur, LoPresti, McEwen, Mueller, Nansen, Planinc, Robert, Schell, Seaborn, Siriaraya, Stopford, Tobiasson, Tobiasson, Ulbrecht, Venugopalan, Weybright   +42 more
core   +2 more sources

APOE‐stratified Proteomic and Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation and Lipid Dysregulation in Alzheimer's Disease

Advanced Science, EarlyView.
A large‐scale multiomic dataset (proteomic and metabolomic) comprising 3,060 plasma samples were analyzed to identify proteins, metabolites, pathways, and protein‐associated drugs linked to Alzheimer’s Disease (AD) independently of apolipoprotein E (APOE). AD was associated with a distinct molecular signature that captures.
Fuhai Li, Yike Chen, Daniel Western, Muhammad Ali, Menghan Liu, Katherine Gong, Ying Xu, Joseph Lowery, David M. Holtzman, Chloe Robins, John D. Eicher, Yen‐Ning Huang, ShiWei Liu, Tamina Park, Andrew J. Saykin, Kwangsik Nho, Mahdi Moqri, Richard C. Mohs, Amelia Farinas, Patricia Moran‐Losada, Hamilton Se‐Hwee Oh, Tony Wyss‐Coray, Carlos Cruchaga   +22 more
wiley   +1 more source

Elderly Body Movement Alteration at 2nd Experience of Digital Art Installation with Cognitive and Motivation Scores

J, 2020
The prevalence of advanced medical treatment has led to global population aging, resulting in increased numbers of dementia patients. One of the most intractable symptoms of dementia is apathy, or lack of interest and enthusiasm, which can accompany ...
Ting Tao, Ryota Sato, Yusuke Matsuda, Jumpei Takata, Fijun Kim, Yukio Daikubara, Koji Fujita, Kotaro Hanamoto, Fumio Kinoshita, Ricki Colman, Mamiko Koshiba   +10 more
doaj   +1 more source

Are methodological quality and completeness of reporting associated with citation-based measures of publication impact? A secondary analysis of a systematic review of dementia biomarker studies [PDF]

, 2018
Objective: To determine whether methodological and reporting quality are associated with surrogate measures of publication impact in the field of dementia biomarker studies.
Drozdowska, Bogna A., Hamilton, Michael, Mackinnon, Shona, McShane, Rupert, Noel-Storr, Anna H., Quinn, Terry   +5 more
core   +2 more sources

Islet Amyloid Polypeptide Modelled to Simulate Diabetes Co‐Oligomerized with β‐Amyloid 1‐42 Reproducing the Pathological Cascade of Alzheimer's Disease in Human Cerebral Organoids

Advanced Science, EarlyView.
Human islet amyloid polypeptide (hIAPP) was used to mimic T2DM, and Aβ42‐hIAPP co‐oligomers were delivered into the human mature cerebral organoids (COs), which reproduce typical AD pathology and significant neuronal death more closely resembling that of AD patients.
Jin Yan, Zhimeng Tang, Yanyu Luo, Bin Liu, Xinxin Huang, Jun Wei, Feng Yue   +6 more
wiley   +1 more source

Digital Tools for People Without an Alzheimer Disease or Dementia Diagnosis: Scoping Review

Journal of Medical Internet Research
BackgroundThe field of Alzheimer disease (AD) has been moving toward earlier detection, personalized assessment of dementia risk, and dementia prevention.
Tanja J de Rijke, Thomas Engelsma, Chi Him Ng, Kyra K M Kaijser, Henk Herman Nap, Ellen M A Smets, Leonie N C Visser   +6 more
doaj   +1 more source