Results 151 to 160 of about 35,977,965 (269)

Time Required for Topical Difluprednate to Suppress the Intradermal Histamine‐Induced Vascular Reaction in Dogs

open access: yesVeterinary Dermatology, EarlyView.
Background: Topical glucocorticoid (GC) is used to manage inflammatory skin diseases in dogs. However, contact times associated with detectable topical GC effects have not been clarified in dogs. Uncertainty regarding contact time may lead to premature removal or overuse, compromising efficacy and safety. Objectives: To determine contact times at which
Fusako Takeo   +2 more
wiley   +1 more source

Severe ADEM‐Like Neuroinflammatory Disease and Cerebrovascular Fragility With Recurrent Pseudoaneurysms and Moyamoya in a Familial Germline CBL Mutation: Expanding the Clinical Phenotype

open access: yesAmerican Journal of Medical Genetics Part A, Volume 200, Issue 11, Page 2568-2574, November 2026.
ABSTRACT Heterozygous germline variants in CBL disrupt its function as a negative regulator of the Ras/MAPK pathway, classically predisposing to Juvenile myelomonocytic leukemia (JMML) and moyamoya. We describe two affected siblings carrying a paternally inherited CBL variant (c.1210 T> C, p.
Michal Bar‐Hakim   +12 more
wiley   +1 more source

Sensitization to Lanolin in North-Eastern Italy, 1997–2021: Prevalence, Risk Factors and the Impact of Occupation

open access: yes
Background: Direct skin contact with items containing lanolin can induce sensitization and development of contact dermatitis (CD). This multi-centric study investigated prevalence of lanolin sensitization among 30,269 outpatients from North-Eastern Italy
Francesca Larese Filon   +2 more
core   +1 more source

From Biological Mechanisms to Causal Inference: Quantitative Systems Pharmacology and Causal Frameworks in Drug Development

open access: yesClinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1255-1265, November 2026.
Digital patients and in silico clinical trials offer new opportunities to advance pharmacological research, clinical development, and regulatory decision‐making by enabling the simulation of treatment effects prior to testing in patients. Among the most promising of these opportunities is the combined use of quantitative systems pharmacology (QSP) and ...
Thomas Klabunde   +3 more
wiley   +1 more source

An experimental model to induce digital dermatitis in beef calves. [PDF]

open access: yesBMC Vet Res, 2022
Thomas AD   +5 more
europepmc   +1 more source

Inflammatory Pseudotumour in Common Seal (Phoca vitulina): A Case Report

open access: yesVeterinary Medicine and Science, Volume 12, Issue 6, November 2026.
A 19‐year‐old intact male common seal (Phoca vitulina) diagnosed with a chronic ulcer. Microbiology identified Vibrio alginolyticus. Radiography noted phalanx alterations. Macroscopic, histopathological, and immunohistochemical examinations revealed a neoplastic origin with a myofibroblastic phenotype. This report describes the first documented case of
Javier M. De Pablo‐Moreno   +7 more
wiley   +1 more source

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