Results 71 to 80 of about 5,998,935 (366)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

The study of the relation between smart phone usage and digital divide in Tehran [PDF]

open access: yesمطالعات رسانه‌های نوین, 2016
Nowadays, many Iranians are using smart phones. Also, the digital divide problem remains an important issue in contemporary urban Iran. Thus, doing research into the relation between these variables is necessary to provide a better understanding of the ...
Babak Rahimi   +3 more
doaj   +1 more source

The digital divide: amplifying health inequalities for people with severe mental illness in the time of COVID-19

open access: yesBritish Journal of Psychiatry, 2021
Summary During COVID-19, health provision and information resources have been increasingly provided via digital means (e.g. websites, apps) and this will become a standard practice beyond the pandemic.
P. Spanakis   +4 more
semanticscholar   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

open access: yesMolecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece   +18 more
wiley   +1 more source

Access to information in digital libraries : users and digital divide [PDF]

open access: yes, 2004
Recognising the importance of information and knowledge in all spheres of human life, the recently held World Summit on Information Society came up with a plan of action for building a global information society. The goal of the world information society
Chowdhury, G.
core  

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

open access: yesMolecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson   +2 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

The grey digital divide and welfare state regimes: a comparative study of European countries

open access: yesInformation Technology and People, 2022
PurposeTechnology access, digital skills, and digital services are increasingly prerequisites for public life and accessing public services. The digital divide in contemporary societies matters for efforts to digitalize the welfare state.
Sofia Alexopoulou   +2 more
semanticscholar   +1 more source

Logic circuit detects both present and missing negative pulses in superimposed wave trains [PDF]

open access: yes, 1967
Pulse divide and determination network provides a logical determination of pulse presence within a data train. The network uses digital logic circuitry to divide positive and negative pulses, to shape the separated pulses, and to determine, by means of ...
Rice, R. E.
core   +1 more source

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