Results 121 to 130 of about 130,289 (305)

Nigra‐Subthalamic Dopaminergic Circuitry Modulates and Represents Distinct Pain Modality in Physiological and Pain States in Mice

Advanced Science, EarlyView.
Nigral dopaminergic (DA) neurons modulate and represent pain with a preference to a particular modality (mechanical) and laterality (contralateral), which are controlled by nigral GABAergic neurons. The pain modulation is mimicked by the nigro‐subthalamic projection and its downstream neurons, involving D2‐like receptors.
Ying Ji, Shuyi Li, Jiaqi Zhang, Xiang‐Ying Xu, Cui Yin, Mu Niu, Danyang Liu, Yanyu Jiang, Yong Niu, Su Liu, Bin Zhang, Guiyun Cui, Chunyi Zhou, Cheng Xiao   +13 more
wiley   +1 more source

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

Advanced Science, EarlyView.
This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang, Yongpeng Qin, Bin Luo, Fan Bai, Jiangyue Liu, Long Ma, Shu He, Rongjie Chen, Yuchen Wang, Shanggong Liu, Ying Sun, Yi Chen, Shuo Zhang, Jiaqi Liang, Feng Liao, Huiyi Wei, Junjie Wei, Lu Wang, Hao Xu, Zheng Wu, Gong Chen, Wenliang Lei   +21 more
wiley   +1 more source

Intelligent recognition method for drilling conditions of deep formation based on LSTM neural network

Discover Applied Sciences
Deep formation drilling is characterized by high investment and risk. Real-time identification of drilling conditions is fundamental and prerequisite for improving drilling efficiency and reducing complex incidents.
Le Jiao, Ping Du, Yuan Yang, Xinxin Fang
doaj   +1 more source

Hill of Banchory Geothermal Energy Project Feasibility Study Report [PDF]

, 2016
This feasibility study explored the potential for a deep geothermal heat project at Hill of Banchory, Aberdeenshire. The geology of the Hill of Fare, to the north of Banchory, gives cause to believe it has good geothermal potential, while the Hill of ...
Feliks, Michael, Gillespie, Martin, Gomez-Rivas, Enrique, McBeth, Neil, Mccay, Alistair, Milligan, Guy, Steen, Paul, Stephenson, Randell, Townsend, David, Townsend, Phil, Wood, George, Younger, Paul   +11 more
core  

Mild Focal Cooling Decouples Dendrites to Reconfigure Cortical Output

Advanced Science, EarlyView.
Mild cooling of the cortical surface selectively modulates apical dendritic excitability, plasticity, and somato‐dendritic coupling, while uncoupling these effects from basal dendrites, and reshapes apical‐driven responses in barrel cortex during whisker touch.
Meisam Habibi Matin, Shulan Xiao, Krishna Jayant   +2 more
wiley   +1 more source

Analysis and evaluation of fragment size distributions in rock blasting at the Erdenet Mine [PDF]

, 2015
Master's Project (M.S.) University of Alaska Fairbanks, 2015Rock blasting is one of the most important operations in mining. It significantly affects the subsequent comminution processes and, therefore, is critical to successful mining productions.
Dondov, Erdenebaatar, Дондов, Эрдэнэбаатар   +1 more
core  

Hierarchical Reconfigurable Metasurface Based on Scenario‐Guided Functional Modules and Programmable Core

Advanced Science, EarlyView.
This paper proposes a hierarchical reconfigurable metasurface architecture (HRMA) to achieve comprehensive electromagnetic parameter modulation and on‐demand polymorphic function switching. The reconfigurable metasurface is divided into a programmable core (PC) and scenario‐guided functional modules (FMs), exhibiting significant flexibility and ...
Lihao Zhu, Jiaqi Han, Zhe Zheng, Qiang Feng, Dexiao Xia, Xiangjin Ma, Yajie Mu, Guoliang Luo, Rui Li, Haixia Liu, Hao Xue, Long Li   +11 more
wiley   +1 more source

In situ digital testing method for quality assessment of soft soil improvement with polyurethane

Journal of Rock Mechanics and Geotechnical Engineering
This study purposes an in situ testing method on quality assessment of soil improvement. Factual drilling data includes the spatial distribution and in situ strength of untreated and treated soil along three different drillholes measured by on-site ...
X.F. Wang, C.J. Wang, W.V. Yue, Z.J. Zhang, Z.Q. Yue   +4 more
doaj   +1 more source

Dynamic Covalent Networks of Molecular Clusters for Hard and Impact‐Resistant Glass with Feasible Processability

Advanced Science, EarlyView.
Molecular granular material glass is fabricated by crosslinking sub‐nm POSS clusters with dynamic borate ester bonding while the materials combine high transparency, modulus, and hardness with superior impact resistance and (re)processability, offering a promising strategy for creating robust yet highly processable organic glasses.
Haiyan Xiao, Jia‐Fu Yin, Linjie Lan, Wei Liu‐Fu, Panchao Yin   +4 more
wiley   +1 more source

Microscopic seepage simulation of gas and water in shale pores and slits based on VOF

Open Physics
The microscopic pore-fracture structure and wettability have a significant influence on the two-phase seepage of shale gas and water. Due to the limitation of experimental conditions, the seepage patterns of gas and water in shale pores and slits under ...
Wang Benqiang, Han Denglin, Lin Wei, Nie Xin, Wang Chenchen, Zhang Jizhen   +5 more
doaj   +1 more source