Results 51 to 60 of about 37,507,659 (251)

Introduction: “Medieval archival sources in the digital world. The challenge of treating and visualizing semi-structured data”

Umanistica Digitale, 2021
The webinar “Medieval archival sources in the digital world. The challenge of treating and visualizing semi-structured data”, organized by the Digital Culture Laboratory (UNIPI) and by the Engineering Historical Memory project. This thematic dossier aims
Enrica Salvatori
doaj   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

Knowledge Representation and Digital Scholarly Editions in Theory and Practice

Journal of the Text Encoding Initiative, 2011
In Transition: Selected Poems by the Baroness Elsa von Freytag-Loringhoven is a publicly available scholarly edition of twelve unpublished poems written by Freytag-Loringhoven between 1923 and 1927.
Tanya Clement
doaj   +1 more source

Sources in Digital Musicology: From Inventories to Interactive Editions [PDF]

, 2020
The book explores the challenges of handling digital data in musicology, particularly focusing on music sources. It investigates the specific aspects of musicology and these documents, which directly affect the creation, organization, and accessibility ...
Pugin, Laurent
core  

GM‐CSF Promotes Neutrophil PD‐L1 Expression Through the VEGFR‐2/STAT6/CSF2 Signaling Axis in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
VEGFR‐2 signaling in OSCC activates Src–STAT6‐dependent CSF2 transcription, driving tumor‐derived GM‐CSF secretion. GM‐CSF programs neutrophils to express PD‐L1 through STAT5–mTOR/S6K signaling, suppressing cytotoxic CD8+ T cells. This pathway reveals a tumor–neutrophil immune checkpoint circuit that limits anti‐PD‐1 responsiveness in OSCC.
Fangxing Zhu, Yuanhe You, Yiyi Zhang, Yibin Dai, Xinyu Zhou, Yong Fu, Xi Lu, Yingying Huang, Zhihang Zhou, Ronghui Xia, Wutong Ju, Zhaoqi Yuan, Laiping Zhong, Tongchao Zhao   +13 more
wiley   +1 more source

csLink - Connect letters across digital scholarly editions

, 2023
The JavaScript widget csLink indicates chronologically neighbouring letters of the correspondence partners from other editions for an edited letter in a digital edition.If you use this software, please cite it using the metadata in the CFF ...
Sobkowski, Steven, Dumont, Stefan, Müller-Laackman, Jonas   +2 more
core   +1 more source

EP300‐Mediated MTF1‐K218 Lactylation Buffers AR‐Driven Copper Overload to Suppress Cuproptosis in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
Androgen receptor (AR) drives copper accumulation in prostate cancer while inducing MTF1 to buffer copper toxicity. EP300‐mediated lactylation of MTF1 at K218 promotes its nuclear translocation and metallothionein expression, sequestering cytosolic copper and preventing mitochondrial cuproptosis.
Kai Li, Yong Wei, Yongshan Li, Yuxiang Dong, Jiancheng Lv, Mingzhi Yuan, Ao Shen, Fuyang Liu, Yetao Zhang, Youjian Li, Ruixi Yu, Yang Liu, Tong Zhao, Jun Wang, Kai Zhou, Zongyao Fan, Manning Wang, Jun Xu, Mulong Du, Min Gu, Bing Yao, Qingyi Zhu   +21 more
wiley   +1 more source

O’Donnell, Daniel Paul. 2005. Cædmon’s Hymn: A multimedia study, edition and archive. Woodbridge: D.S. Brewer. xxii + 261 pages + CD-ROM.

Digital Medievalist, 2009
 Cædmon’s Hymn is the name given to a poem recorded in Old English in some manuscripts of Bede’s Historia Ecclesiastica, an ecclesiastical history of the English people written in the early eighth century at Wearmouth-Jarrow in Northumbria.
Peter A. Stokes
doaj   +1 more source

Developing Metal–Polyphenol Network‐Based Single‐Protein Particle Encapsulation System for Sustained Release of Whey Protein to Mitigate Sarcopenia

Advanced Science, EarlyView.
Sarcopenia has emerged as a major health challenge in the aging population. Developing a sustained‐release system for whey protein may enhance its effectiveness in mitigating sarcopenia. Herein, a novel “single‐protein particle encapsulation” (SPPE) system is developed to protect whey protein and control its release.
Yafei Zhang, Yuning Zhang, Yongjian Ai, Yao Lu, Heng Quan, Zhen Zhang, Yuqi Wang, Yujia Luo, Xiaoxu Zhang, Yingying Lin, Sijia Song, Huiyuan Guo   +11 more
wiley   +1 more source

The Visual [Re]Presentation of Textual Data in Traditional and Digital Critical Editions

magazén, 2022
The prospect of breaking free from the confines of the printed page drives much of the interest in digital critical editions; yet the format of traditional editions in print remains an effective and efficient information visualization. This paper will
Huskey, Samuel
doaj   +1 more source