Results 31 to 40 of about 117,298 (306)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

Application of digital elevation model for mapping vegetation tiers

open access: yesJournal of Forest Science, 2010
The aim of this paper is to explore possibilities of application of digital elevation model for mapping vegetation tiers (altitudinal vegetation zones).
D. Volařík
doaj   +1 more source

Void Filling of Digital Elevation Models With Deep Generative Models [PDF]

open access: yesIEEE Geoscience and Remote Sensing Letters, 2019
5 pages; 4 figures; corrected names in references; clarifications regarding the two generators in the paper; added reference (Borji 2018) on GAN evaluation measures; extended future work discussion; changed (Fig.
Konstantinos Gavriil   +2 more
openaire   +2 more sources

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

DEVELOPMENT OF A DIGITAL ELEVATION MODEL OF KARA-BOGAZ-GOL BAY

open access: yesTransactions of the Karelian Research Centre of the Russian Academy of Sciences, 2020
The article presents the results of the efforts to create a digital elevation model of Kara-Bogaz-Gol Bay. The informational background for the digital elevation model was maps of 1:200 000 and 1:100 000 scales. The digital elevation model was created by
Tatiana Vyruchalkina
doaj   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

open access: yesFEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia   +6 more
wiley   +1 more source

Differences between 100-meter and 25-meter digital elevation models according to types of relief in Slovenia

open access: yesActa Geographica Slovenica, 2005
Studying relief and landscapes, we often employ digital elevation models. Their applicability is primarily linked to their accuracy. In this paper, we compare the older 100-meter digital elevation model of Slovenia and the more recent 25-meter digital ...
Mauro Hrvatin, Drago Perko
doaj   +1 more source

The TanDEM-X Digital Elevation Model and Terrestrial Impact Structures

open access: yesIEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, 2021
We utilized the TanDEM-X digital elevation model (DEM) for investigating the complete record of confirmed terrestrial impact structures with respect to its suitability to support geological analysis.
Manfred Gottwald   +4 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

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