Results 51 to 60 of about 38,645,875 (330)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Digital preservation in the Tertiary education sector : management implications [PDF]

, 2006
This paper assesses the future of long-term curation and preservation of digital assets with particular reference to Further Education (FE) in the UK. Reviews current requirements of digital preservation and the efforts underway to support them.
Robertson, R. John
core   +4 more sources

Digital Assets as a Tool for Intelligent Industrial Production

Мир новой экономики
Relevance. Intelligent industrial production involves not only the introduction of digital technologies, but also the active use of digital assets obtained with their application, which requires the study of their functionality as a toolkit for a single ...
O. V. Loseva
doaj   +1 more source

Alternative Assets and Cryptocurrencies

, 2019
Alternative assets, defined by their low correlation with classical financial assets, have become an important investment vehicle in times of negative interest rates and in the aftermath of the global economic and financial crisis.
Hafner, Christian M., Christian M. Hafner   +1 more
core   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Legal regulation of digital financial assets – requirements for the transfer of securities of a business entity

Правоприменение
Introduction. In modern Russia, digital investment technologies are actively developing and legitimized at the level of law enforcement, including for such an economic entity as a non-public joint-stock company.
A. I. Goncharov, M. V. Goncharova, A. A. Orlova   +2 more
doaj   +1 more source

Development of the circulation of digital financial assets in the world in the context of digital transformation

Economics and Management
Aim. To study and describe the main trends in the development of the world market of digital financial assets in the conditions of digital transformation. Objectives.
E. S. Ivleva, M. Makarov, A. Bobrov
semanticscholar   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

The Effect of Digital Asset Recognition on The Accuracy of Auditors’ Opinion: An Experimental Study [PDF]

المجلة العلمية للبحوث التجارية - جامعة المنوفية
The purpose of this paper is to analyze and examine the effect of digital asset recognition on the accuracy of auditors’ unqualified and qualified opinion on financial statements.
سمر فتحي عبد الجواد سليمان سليمان
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source