Results 101 to 110 of about 2,251,696 (313)

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Survival Prediction for Non-Small Cell Lung Cancer Based on Multimodal Fusion and Deep Learning

IEEE Access
Non-small cell Lung Cancer (NSCLC) is one of the most common types of lung cancer, accounting for approximately 80% to 85% of lung cancer cases, and survival prediction in this cancer is an essential medical task. Traditional survival prediction methods,
Xiaopu Ma, Fei Ning, Xiaofeng Xu, Jiangdan Shan, He Li, Xiao Tian, Shuai Li   +6 more
doaj   +1 more source

A Fundamental Group for Digital Images [PDF]

arXiv, 2019
We define a fundamental group for digital images. Namely, we construct a functor from digital images to groups, which closely resembles the ordinary fundamental group from algebraic topology. Our construction differs in several basic ways from previously established versions of a fundamental group in the digital setting.
arxiv  

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

TM digital image products for applications [PDF]

Computer compatible tapes (CCTs) of LANDSAT 4 thematic mapper (TM) digital image products are compared and reviewed. The following tape formats are discussed: (1) raw band-sequential data (CCT-BT); (2) calibrated data (CCT-AT); and (3) geometrically ...
Abrams, R. B., Ball, D., Barker, J. L., Gunther, F. J.   +3 more
core   +4 more sources

Segmentation of Myocardial Boundaries in Tagged Cardiac MRI Using Active Contours: A Gradient-Based Approach Integrating Texture Analysis

International Journal of Biomedical Imaging, 2009
The noninvasive assessment of cardiac function is of first importance for the diagnosis of cardiovascular diseases. Among all medical scanners only a few enables radiologists to evaluate the local cardiac motion. Tagged cardiac MRI is one of them.
Aymeric Histace, Bogdan Matuszewski, Yan Zhang   +2 more
doaj   +1 more source

Digital mammography, cancer screening: Factors important for image compression [PDF]

The use of digital mammography for breast cancer screening poses several novel problems such as development of digital sensors, computer assisted diagnosis (CAD) methods for image noise suppression, enhancement, and pattern recognition, compression ...
Blaine, G. James, Brown, G. Stephen, Clarke, Laurence P., Doi, Kunio, Kallergi, Maria, Shtern, Faina, Winfield, Daniel L., Yaffe, Martin J.   +7 more
core   +1 more source

Expression and purification of E140 protein antigen fragments of Plasmodium vivax and Plasmodium berghei for serological assays

FEBS Open Bio, Volume 15, Issue 5, Page 690-698, May 2025.
We provide a step‐by‐step guide for producing E140 antigen fragments from Plasmodium berghei (Pb1) and Plasmodium vivax (Pv1). Pb1/Pv1 are expressed in E. coli, solubilized by freeze–thawing, refolded by slow dilution, purified by affinity chromatography (IMAC), then concentrated and subjected to quality control.
Rodolfo Ferreira Marques, Edit Ábrahám, Hiromi Muramatsu, Daniel Youssef Bargieri, Norbert Pardi, Zoltán Lipinszki   +5 more
wiley   +1 more source

Identification of asymmetrical abnormalities in functional connectivity and brain network topology for migraine sufferers: A preliminary study based on resting-state fMRI data

Brain Research Bulletin
Research on the neural mechanisms underlying brain asymmetry in patients with migraine patients using fMRI is insufficient. This study proposed using lateralized algorithms for functional connectivity and brain network topology and investigated changes ...
Weifang Nie, Weiming Zeng, Jiajun Yang, Lei Wang, Yuhu Shi   +4 more
doaj