Results 51 to 60 of about 811,574 (294)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Multi-scale crack closure measurements with digital image correlation on Haynes 230

Fracture and Structural Integrity, 2015
An experimental campaign was developed to study fatigue crack growth in Haynes 230, a Ni-based superalloy. The effects of crack closure were investigated with digital image correlation, by applying two different approaches.
Stefano Beretta, Silvio Rabbolini, Angelo Di Bello, Huseyin Sehitoglu   +3 more
doaj  

Impact of Speckle Deformability on Digital Imaging Correlation

IEEE Access
Digital Image Correlation (DIC) has been widely used as a non-contact deformation measurement technique. Nevertheless, its accuracy is greatly affected by the speckle pattern on the specimen. To systematically evaluate how speckle deformability affects the precision of DIC algorithms.
Jiaqiu Wang, Hao Wu, Zhengduo Zhu, Hujin Xie, Han Yu, Qiuxiang Huang, Yuqiao Xiang, Phani Kumari Paritala, Jessica Benitez Mendieta, Haveena Anbananthan, Jorge Alberto Amaya Catano, Runxin Fang, Luping Wang 0008, Zhiyong Li   +13 more
openaire   +4 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Stress induced martensite at the crack tip in NiTi alloys during fatigue loading

Fracture and Structural Integrity, 2014
Crack tip stress-induced phase transformation mechanisms in nickel-titanium alloys (NiTi) were analyzed by Digital Image Correlation (DIC), under fatigue loads.
E. Sgambitterra, L. Bruno, C. Maletta
doaj  

A new digital image correlation software for displacements field measurement in structural applications [PDF]

Recently, there has been a growing interest in studying non-contact techniques for strain and displacement measurement. Within photogrammetry, Digital Image Correlation (DIC) has received particular attention thanks to the recent advances in the field of
Belloni, Valeria, Crespi, Mattia Giovanni, Di Rita, Martina, Mattei, Domitilla, Nascetti, Andrea, Nistico', Nicola, Ravanelli, Roberta   +6 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Applications of digital image correlation to biological tissues

Journal of Biomedical Optics, 2004
Optical methods are becoming commonplace in investigations of the physical and mechanical behavior of biological tissues. Digital image correlation (DIC) is a versatile optical method that shows tremendous promise for applications involving biological tissues and biomaterials.
Dongsheng, Zhang, Dwayne D, Arola
openaire   +2 more sources