Results 51 to 60 of about 214,999 (300)
IEEE Access, 2017 Smart cities are a future reality for municipalities around the world. Healthcare services play a vital role in the transformation of traditional cities into smart cities.
Muhammad Sajjad +8 more
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Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Discover EnvironmentInformal settlements (ISs), characterized by unauthorized occupation and construction without legal recognition, represent a critical urban challenge in rapidly developing cities like Addis Ababa, Ethiopia, where 23.8% of the urban population resides in ...
Alazer Bergene Bante +3 more
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Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Multiscale lung nodule segmentation based on 3D coordinate attention and edge enhancement
Electronic Research ArchiveAn important prerequisite for improving the reliability of lung cancer surveillance and clinical interventions is accurate lung nodule segmentation. Although deep learning is effective at performing medical image segmentation, lung CT image heterogeneity,
Jinjiang Liu +4 more
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Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Weakly Supervised Adversarial Training for Remote Sensing Image Cloud and Snow Detection
IEEE Journal of Selected Topics in Applied Earth Observations and Remote SensingCloud and snow detection in remote sensing images has advanced significantly with the aid of deep learning methods. However, deep learning methods necessitate a large quantity of labeled data, which consumes a substantial amount of human and material ...
Jiajun Yang +5 more
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FEBS Open Bio, EarlyView.Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar +3 more
wiley +1 more source
Sensors, 2015 This paper presents a novel auto-focusing system based on a CMOS sensor containing pixels with different phases. Robust extraction of features in a severely defocused image is the fundamental problem of a phase-difference auto-focusing system.
Jinbeum Jang +3 more
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