Results 91 to 100 of about 54,970 (293)

Evaluating digital humanities resources: The LAIRAH project checklist and the internet Shakespeare editions project

, 2007
The following paper presents a case study of the way that the research done by the LAIRAH project may be applied in the case of a real digital resource for humanities scholarship.
C. Warwick, P. Huntington, Warwick, C., M. Terras, Terras, M., Warwick, C, Huntington, P., Terras, M, Huntington, P, I. Galina, M. Pappa, Galina, I., Pappa, N, Pappa, N., Galina, I   +14 more
core  

A novel in vivo method to evaluate trueness of digital impressions

BMC Oral Health, 2018
Background Intraoral scanners are devices for capturing digital impressions in dentistry. Until now, several in vitro studies have assessed the trueness of digital impressions, but in vivo studies are missing.
Emad A. Albdour, Eman Shaheen, Myrthel Vranckx, Francesco Guido Mangano, Constantinus Politis, Reinhilde Jacobs   +5 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Comparison of Vertical Marginal Fitness of Zirconia Overlay Fabricated Using Conventional and Two Digital Impression Technology: An In Vitro Study

Dental Hypotheses
Introduction: We aimed to compare the vertical marginal fitness measurement of indirect zirconia overlay restorations fabricated using conventional and two types of digital impression technologies.
Hala Mohammed Hussein, Mohammed Kassim Gholam   +1 more
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Conventional and digital complete-arch implant impression techniques: an in vitro study comparing accuracy

Statement of problem: Varying complete arch digital-implant-scanning techniques have been described, but their accuracy remains uncertain. Purpose: The purpose of this in vitro investigation was to assess the effect of the implant angulation and ...
Revilla-León, Marta, Cascos, Rocío, Gómez Polo, Miguel Ángel, Ballesteros, Juan, Barmak, Abdul Bassir, Sallorenzo, Alessandro   +5 more
core   +1 more source

Comparative Evaluation of Conventional and Digital Workflow Impressions for Implant-Supported Restorations

Dentistry Journal
Background: Digital technologies, particularly CAD/CAM workflows, have transformed implant prosthodontics by improving the accuracy and efficiency of impression procedures, facilitating clinician–laboratory communication, and supporting the preservation ...
Cristian Abad-Coronel, David Ruiz, Miguel Ángel Quelal, Diana Estrada, Nancy Mena Córdova, Paulina Aliaga   +5 more
doaj   +1 more source