Results 131 to 140 of about 553,132 (294)

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Inclusive Digital Gaming Platform

Multimedia
The lack of accessibility in digital gaming platforms remains a significant barrier to equitable user participation. To address this issue, this article presents an inclusive solution developed as a multimedia project designed to promote access to digital games for any user through the ipcb.games platform.
Mendonça, Rodrigo, Lopes, Salvador, Oliveira, Ângela, Serra, Paulo, Fidalgo, Filipe   +4 more
openaire   +2 more sources

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

Digital Inclusion Strategies: A Primer for Latin American Policymakers [PDF]

Digital policies without inclusion principles risk underperforming and having a reduced impact. As more countries look to scale up their digital economies and create favorable investment conditions for information and communication technologies ...
Inter-American Development Bank
core   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Social Deprivation and Digital Exclusion in England

, 2008
Issues of digital exclusion are now increasingly considered alongside those of material deprivation when formulating interventions in neighbourhood renewal and other local policy interventions in health, policing and education.
Singleton, A, Longley, P
core  

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Exploring the nexus of digital inclusion and environmental sustainability: insights from Cambodia

This research examines the confluence of digital inclusion and environmental sustainability in Cambodia, utilizing quantitative survey data from 380 participants.
Doeur, Bunhorn, Sorn, Savoeun, Dem, Tithsatya, Ly, Bora, Ly, Romny   +4 more
core   +1 more source

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

Evaluating Web Accessibility in Countries Included in the Latin American Artificial Intelligence Index

IEEE Access
This study examines the relationship between the Latin American Artificial Intelligence Index (ILIA) and the Web Accessibility Index (WAIN) in 19 Latin American countries to evaluate how technological innovation aligns with digital inclusivity.
Patricia Acosta-Vargas, Belen Salvador-Acosta, Mauricio Loachamin-Valencia, Marcos Chacon-Castro, Janio Jadan-Guerrero, Luis Salvador-Ullauri   +5 more
doaj   +1 more source