Results 51 to 60 of about 36,238,560 (283)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Problematizing the Adoption of Formal Methods in the 4IR–5IR Transition

Applied System Innovation, 2022
The adoption of formal methods (FMs) as a software development methodology remains low. Advocates of FMs point to the advantages to be gained by producing highly dependable systems, while critics refer to the steep learning curve required to master the ...
John Andrew van der Poll
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Association of Leadership Educators 28th Annual Conference

, 2020
This poster discusses the leadership development outcome of the Virginia Governor’s School of Agriculture (VGSA), a pre-college residential program, whose mission is to develop future leaders and scientists for careers in agriculture.
Alegbeleye, Ibukun Dami, Kaufman, Eric K., Omosa, Oladayo, Friedel, Curtis R.   +3 more
core  

What is Good Leadership? [PDF]

, 2004
The moral triumphs and failures of leaders carry a greater weight and volume than those of nonleaders. In leadership we see morality and immorality magnified, which is why ethics is fundamental to our understanding of leadership.
Ciulla, Joanne B.
core  

Digital Leadership And Institutional Performance In Higher Education: Faculty Digital Readiness As A Mediating Capability

Journal of Asia Entrepreneurship and Sustainability
Digital transformation in higher education requires more than technology adoption; it depends on leadership capability, faculty readiness, and the ability of institutions to convert digital strategy into academic practice. This study examines how Digital
Mrs. Kavitha Kothari, Dr. M.R. Jhansi Rani, Dr. Anand Shankar Raja M   +2 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Advancing tendencies? PR leadership, general leadership, and leadership pedagogy [PDF]

, 2014
What are the best ways to advance PR leadership? In exploring answers, we consider the last two decades of PR literature and identify two main tendencies.
Willis, Paul, Willis, P, McKie, D, McKie, David   +3 more
core   +1 more source

Bibliometric Analysis of Digital Leadership Studies

Mehmet Akif Ersoy Üniversitesi İktisadi ve İdari Bilimler Fakültesi Dergisi
The purpose of this study is to provide a comprehensive and holistic perspective on the field of digital leadership by conducting a bibliometric analysis of publications in this field. Web of Science (WoS) Core Collection database was utilized to gateher
Sena Erden Ayhün, İsmail Şimşir, Selma Kılıç Kırılmaz, Erdal Aydın   +3 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source