Results 61 to 70 of about 139,843 (276)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Leadership Lambda Collection

, 1998
3 pages: Leadership Lambda, Inc. cover sheet, a 1998-1999 Seminar Series roster of participants, and a list of the 1998-1999 class.
Leadership Lambda, Inc.
core   +1 more source

Exploring the evolution of leadership in government: a bibliometric study from e-government era into the digital age

Cogent Social Sciences
This study offers a comprehensive exploration of the evolution of leadership research within the digital transformation of the governmental sector, a subject increasingly relevant in our digital world.
Huda M. Elmatsani, Ida Widianingsih, Heru Nurasa, M. D. Enjat Munajat, Supriana Suwanda   +4 more
doaj   +1 more source

Leadership 4.0: Navigating the Challenges of the Digital Transformation in Healthcare and Beyond

The Fourth Industrial Revolution (4IR), characterized by the integration of advanced digital technologies, is transforming industries globally and significantly impacting leadership practices, particularly in the healthcare sector. As organizations adapt
Anastasia Vasileiou, Georgios Tsekouropoulos, Dimitrios Theocharis, Greta Hoxha, Theodosios Grigoriadis, Efthimia Theodoridou   +5 more
core   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Evolution of strategy narration and leadership work in the digital era

, 2019
This paper examines the evolution of strategy narration, contributing to ongoing discussions in this field. Our empirical data, gathered from a large Finnish co-operative bank, cover three decades.
Sajasalo, Pasi, Auvinen, Tommi, Takala, Tuomo, Sintonen, Teppo, Pekkala, Kaisa, Luoma-aho, Vilma   +5 more
core   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Using the new positive aspect of digital leadership to improve organizational sustainability: Testing moderated mediation model

Acta Psychologica
In the era of digital transformation, the role of digital leadership in companies is continuously demanded and its importance is increasingly emphasized.
Zian Cheng, Xiu Jin, Won Jun Kwak
doaj   +1 more source

The Role of Leadership in a Digitalized World: A Review [PDF]

Frontiers in Psychology, 2019
Digital technology has changed organizations in an irreversible way. Like the movable type printing accelerated the evolution of our history, digitalization is shaping organizations, work environment and processes, creating new challenges leaders have to face. Social science scholars have been trying to understand this multifaceted phenomenon, however,
Laura Cortellazzo, Elena Bruni, Elena Bruni, Rita Zampieri   +3 more
openaire   +4 more sources

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source