Results 51 to 60 of about 213,525 (300)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Effect of Scraper Geometry on Scraping HAP/ZrO2 Slurry in Digital Light Processing

Advances in Mathematical Physics, 2021
Digital light processing (DLP) can be used to form HAP/ZrO2 mixed ceramic slurry. In the printing technology, the scraper geometry has an important effect on the scraping process; thus, it is necessary to conduct analysis.
Hai Gu, Jie Zhang, Jianhua Sun, Tiancheng Huang, Jie Jiang, Bin Li, Weiwei Wu   +6 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Digital reconstruction of squeezed light for quantum information processing

npj Quantum Information
Squeezed light plays a vital role in quantum information processing. However, its highly sensitive nature presents significant practical challenges, particularly in remote detection, which traditionally requires complex systems such as active phase ...
Huy Q. Nguyen, Ivan Derkach, Adnan A. E. Hajomer, Hou-Man Chin, Akash nag Oruganti, Ulrik L. Andersen, Vladyslav Usenko, Tobias Gehring   +7 more
doaj   +1 more source

Facile synthesis of chitosan/Ag-waterborne polyurethane composite films with a high stability and controllable water resistance for potential application in antibacterial materials

Journal of Materials Research and Technology, 2021
Waterborne polyurethane (WPU) and Ag NPs have been applied widely in packaging. However, WPU was susceptible to the contamination due to high moisture absorption, and the stability of Ag NPs in matrix polymers was still low.
Youliang Cheng, Ying Wei, Changqing Fang, Hang Li, Jing Chen, Jin Zhang, Zhigang Huang   +6 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

220-320 GHz Hemispherical Lens Antennas Using Digital Light Processed Photopolymers

IEEE Access, 2019
This paper presents a 220-320-GHz hemispherical lens antenna fabricated using photopolymer-based additive manufacture and directly fed by the standard WR-3 rectangular waveguide without any additional waveguide extension.
Nonchanutt Chudpooti, Nattapong Duangrit, Prayoot Akkaraekthalin, Ian D. Robertson, Nutapong Somjit   +4 more
doaj   +1 more source

Particle-free compositions for printing dense 3D ceramic structures by digital light processing

Virtual and Physical Prototyping, 2021
UV-curable particle-free ceramic compositions for stereolithography-based 3D printing technologies present a promising alternative to the commonly used particle-based compositions.
Tamar Rosental, Sapir Mizrahi, Alexander Kamyshny, Shlomo Magdassi   +3 more
doaj   +1 more source

Advances in precision microfabrication through digital light processing

Virtual and Physical Prototyping, 2023
Digital Light Processing (DLP) is an advanced additive manufacturing technology which has garnered substantial recognition and has been extensively applications in various fields. This review focuses on the precision microfabrication process of DLP, providing an overview of the DLP 3D printing system, including the digital light engine, project lenses,
Wang, Xinhui, Liu, Jinghang, Zhang, Yang, Kristiansen, Per Magnus, Islam, Aminul, Gilchrist, Michael, Zhang, Nan   +6 more
openaire   +1 more source