Results 81 to 90 of about 2,898,823 (286)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

El ordenador como máquina performativa

open access: yesCaracteres: Estudios Culturales y Críticos de la Esfera Digital, 2014
This article aims to approach the relationship between art and technology to reach the so-called “digital literatures”. For that purpose we pretend to develop the evolution of the technical creation (drawing and writing are considered as technical ...
Laura Sánchez Gomez
doaj  

Electronic books: Are they effective educational tools for students who are deaf or hard of hearing? [PDF]

open access: yes, 2016
This literature review will examine the effectiveness of electronic book features on students’ reading development in the general education population and investigate whether or not these digital tools could be a useful tool and/or supplement in literacy
Vaughan, Ainsley
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Modos de puntuar el tiempo en producciones de literatura digital argentina

open access: yesCuadernos LIRICO
In this paper, we are interested in the articulated study of a series of Argentinian digital literature productions : The Spell (Solaas 2021), Un segundo (Scarlato 2023), Trenza (Costello 2020) and Voy a tener suerte (anonymous author 2020).
Fernanda Mugica
doaj   +1 more source

No. 110 10.4.93-10.7.93 or Polish uncreative writing

open access: yesMatLit, 2016
This article provides an overview of Polish digital literature, using the tools and vocabulary of uncreative writing put forward by American artist and theorist Kenneth Goldsmith.
Marecki, Piotr
doaj   +1 more source

LIFE: Costing the digital preservation lifecycle [PDF]

open access: yes, 2007
Having confidence in the permanence of a digital resource requires a deep understanding of the preservation activities that will need to be performed throughout its lifetime, and an ability to plan and resource for those activities.
Ayris, Paul   +4 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

"A Painful Homecoming": Harry Potter Fanfiction and Nostalgia via All the Young Dudes by MsKingBean89

open access: yesDiffractions
In this paper, I will consider fanfiction as an inherently nostalgic group of texts, an argument that has not yet been explored in much detail within fan studies. A close reading of one of the most popular Harry Potter fanfictions, MsKingBean89’s All the
Nina Heise
doaj   +1 more source

Engineering stories? A narratological approach to children's book apps

open access: yesBarnelitterært Forskningstidsskrift, 2014
With the rise of smartphones and tablet pcs, children's book apps have emerged as a new type of children's media. While some of them are based on popular children's books such as Mo Willems’ Pigeon books or Beatrix Potter's Peter Rabbit, others were ...
Hadassah Stichnothe
doaj   +1 more source

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