Results 61 to 70 of about 36,960,886 (296)
Protocol for quantifying miRNA trafficking across the endosomal membrane
FEBS Open Bio, EarlyView.An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source
Digital and virtual manufacturing engineering
, 2022 4 S.Manufacturing is a dynamic socio-technical system, which is operating in a turbulent environment. Changes are normal and continuous at all levels.
Constantinescu, C. +2 more
core +1 more source
FEBS Open Bio, EarlyView.The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti +5 more
wiley +1 more source
Chinese Journal of Mechanical Engineering, 2023 The meta-heuristic algorithm with local search is an excellent choice for the job-shop scheduling problem (JSP). However, due to the unique nature of the JSP, local search may generate infeasible neighbourhood solutions.
Lin Gui, Xinyu Li, Liang Gao, Cuiyu Wang
doaj +1 more source
GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma
FEBS Open Bio, EarlyView.GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain +11 more
wiley +1 more source
Integrated Production and Transportation Scheduling Method in Hybrid Flow Shop
Chinese Journal of Mechanical Engineering, 2022 The connection between production scheduling and transportation scheduling is getting closer in smart manufacturing system, and both of those problems are summarized as NP-hard problems.
Wangming Li +4 more
doaj +1 more source
Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells
FEBS Open Bio, EarlyView.Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla +10 more
wiley +1 more source
Digitalization in the Manufacturing Sector: Skills in Transition
, 2018 With the introduction of new machining technologies in his workplace, 50-year-old machine operator Paul Sandberg is confronted with the realisation that the skills and experience that he's gained on the job over the course of his career are now mostly worthless.
Kleinsmith, Niela +2 more
openaire +2 more sources
Upper Cervical Cord Area as a Biomarker of Conversion to Secondary Progressive Multiple Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective This study assessed whether upper cervical cord area (UCCA) measured on routine brain MRI can serve as a biomarker of conversion to SPMS. Methods This is a single‐center retrospective cohort study of RRMS patients with cross‐sectional and longitudinal analyses of clinical and MRI data. Future SPMS converters were matched by age, sex,
Nabil K. El Ayoubi +8 more
wiley +1 more source
MATEC Web of Conferences, 2017 A framework of non-intrusive polynomial chaos expansion method (PC) was proposed to investigate the statistic characteristics of the response of structural-acoustic system containing random uncertainty.
Wang Mingjie +4 more
doaj +1 more source