Results 101 to 110 of about 14,996,800 (353)

Sending your research material into the future [PDF]

open access: yes, 2012
A leaflet offering practical guidance for researchers on how to preserve their digital research material/data. This is one of the outputs of the JISC SHARD project, investigating research data preservation for history researchers, and related projects in
Collins, Anna   +2 more
core  

Readout fidelity of coaxial holographic digital data page recording in nanoparticle–(thiol–ene) polymer composites [PDF]

open access: yes, 2016
We report on an experimental investigation of nanoparticle-concentration and thiol-to-ene stoichiometric ratio dependences of symbol error rates (SERs) and signal-to-noise ratios (SNRs) of digital data pages recorded at a wavelength of 532 nm in thiol ...
Eiji Hata, Kohta Nagaya, Yasuo Tomita
core   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

Low concentration flufenamic acid enhances osteogenic differentiation of mesenchymal stem cells and suppresses bone loss by inhibition of the NF-κB signaling pathway

open access: yesStem Cell Research & Therapy, 2019
Background As the representative of fenamic acids, an important group of NSAIDs, flufenamic acid (FFA) has been used for anti-inflammation and analgesia in the clinic.
Xuenan Liu   +10 more
doaj   +1 more source

Plastic pre-compression and creep damage effects on the fracture toughness behaviour of Type 316H stainless steel [PDF]

open access: yes, 2014
The influence of inelastic damage in the form of plastic pre-strain and creep damage, on fracture toughness of Type 316H stainless steel has been examined.
Davies, C. M.   +3 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

Digital materiality

open access: yesTrayectorias Humanas Trascontinentales
In 2017, Google's “Attention is All You Need” (Vaswani et al.) introduced the Transformer architecture, laying the groundwork for today’s large language models (LLMs) like GPT, Claude, and Llama. Transformers excel at processing sequences by leveraging self-attention, which allows for the dynamic weighting of relationships between words in a sentence ...
openaire   +2 more sources

Teaching and Professional Fellowship Report 2002/3: Colour and Computing [PDF]

open access: yes, 2003
An exploration of new teaching and learning methodologies relating material colour use to digital colour and the computer's speed, control, 'sensitivity' and new possibilities to develop colour ideas of practical use in the ...
Lewis, Garth
core  

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

'When I click "ok" I become Sassy – I become a girl.' Young people and gender identity: Subverting the ‘body’ in massively multi-player online role-playing games [PDF]

open access: yes, 2012
This article is available open access through the publisher’s website through the link below. Copyright @ 2012 Taylor & Francis.This article explores young people's practices in the virtual spaces of online gaming communities.
Althusser L.   +11 more
core   +1 more source

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