Results 111 to 120 of about 14,996,800 (353)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Post-digital humanities: computation and cultural critique in the arts and humanities [PDF]

, 2014
Today we live in computational abundance whereby our everyday lives and the environment that surrounds us are suffused with digital technologies. This is a world of anticipatory technology and contextual computing that uses smart diffused computational ...
Berry, David M
core   +1 more source

Experimental study of artificial neural networks using a digital memristor simulator [PDF]

, 2018
© 2018 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes,creating new ...
Abusleme, Angel, Ntinas, Vasileios, Rubio Sola, Jose Antonio, Sirakoulis, Georgios, Vourkas, Ioannis   +4 more
core   +2 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

A nomogram prediction of gingival recession in mandibular incisors of orthodontic-orthognathic treated skeletal class III malocclusion with or without PAOO: A retrospective cohort study

Heliyon
Background: To assess the alterations in gingival thickness and the occurrence gingival recession subsequent to orthodontic-orthognathic treatment of mandibular incisors in skeletal Class III and identify risk factors associated with gingival recession ...
Jian Liu, Xiao Xu, Hui-Fang Yang, Ye Han, Meng-Qiao Pan, Li Xu, Jian-Xia Hou, Xiao-Tong Li   +7 more
doaj   +1 more source

Advancements in Hydrogel-Based Drug Sustained Release Systems for Bone Tissue Engineering

Frontiers in Pharmacology, 2020
Bone defects caused by injury, disease, or congenital deformity remain a major health concern, and efficiently regenerating bone is a prominent clinical demand worldwide.
Yunfan Zhang, Tingting Yu, Liying Peng, Qiannan Sun, Yan Wei, Bing Han   +5 more
doaj   +1 more source

Code of Best Practices in Fair Use for the Visual Arts [PDF]

, 2015
This Code of Best Practices provides visual-arts professionals with a set of principles addressing best practices in the fair use of copyrighted materials.

core  

Digital inequalities in the Internet of Things: differences in attitudes, material access, skills, and usage

Information, Communication & Society, 2019
The Internet of Things (IoT) is more complex and abstract than previous information and communication technologies as there are many connections occurring.
A. V. van Deursen, Alex van der Zeeuw, Pia S de Boer, Giedo Jansen, T. V. van Rompay   +4 more
semanticscholar   +1 more source

Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education

FEBS Open Bio, EarlyView.
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman, Jessica Haines, Connie Pritchard, Stephen Rutherford, Nigel Francis   +4 more
wiley   +1 more source