Results 101 to 110 of about 3,337,648 (329)

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

Digital Maturity Model

, 2022
In Gesellschaften, in denen schnelle Veränderungen und unregelmäßige technologische Veränderungen üblich sind, haben kleine und mittlere Unternehmen (KMU) Schwierigkeiten, mit diesen grundlegenden Veränderungen Schritt zu halten. Verschiedene externe und interne Hürden hindern KMUs daran, die digitale Lücke zwischen ihren eigenen digitalen Initiativen ...
openaire   +1 more source

Digital Preservation Services : State of the Art Analysis [PDF]

, 2012
Research report funded by the DC-NET project.An overview of the state of the art in service provision for digital preservation and curation. Its focus is on the areas where bridging the gaps is needed between e-Infrastructures and efficient and forward ...
Dobreva, Milena, Ruusalepp, Raivo
core  

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Measuring the Digital Maturity of Organisations in the People Care Sector

Sustainability
This study focuses on the organisations in the people care sector (OPCs), encompassing a broad spectrum of activities ranging from essential healthcare services to various aspects of daily living support.
Nikola Kadoić, Teresa Monllau Jaques, Jaime Lacueva Rueda   +2 more
semanticscholar   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Digital maturity of industrial enterprises: Evaluation experience

St Petersburg University Journal of Economic Studies
The article is devoted to the study of theoretical and practical aspects of assessing the digital maturity of enterprises and their readiness for digital transformation in accordance with the challenges of the digital economy.
I. Krakovskaya, J. Korokoshko, Y. Slushkina   +2 more
semanticscholar   +1 more source

Meeting their potential: the role of education and technology in overcoming disadvantage and disaffection in young people [PDF]

, 2008
This report is a review of literature, policy and reported practice, exploring the potential of technology to mitigate disaffection and disadvantage in education and raise attainment of those young people who are under-achieving in school or other ...
.,, Alvi, Imran, Bradbrook, Gail, Brake, David, Fisher, John, Helsper, Ellen, Livingstone, Sonia, Lloyd, Heidi, Moore, Ray, Thompson, Valerie   +9 more
core  

A Scoping Review on Artificial Intelligence–Supported Interventions for Nonpharmacologic Management of Chronic Rheumatic Diseases

Arthritis Care &Research, EarlyView.
This review summarizes artificial intelligence (AI)‐supported nonpharmacological interventions for adults with chronic rheumatic diseases, detailing their components, purpose, and current evidence base. We searched Embase, PubMed, Cochrane, and Scopus databases for studies describing AI‐supported interventions for adults with chronic rheumatic diseases.
Nirali Shah, Alexis Castellanos, Yen Chen, John Piette, Amy Bucher, Susan Murphy   +5 more
wiley   +1 more source

Government Digital Transformation: A Tailor-Made Digital Maturity Assessment Framework

IEEE Access
Governments seek to implement digital transformation initiatives to improve the effectiveness of their public services. To achieve this, governments need to assess their IT environment and evaluate their digital maturity.
Muna Alfadhli, Murat Kucukvar, Nuri C. Onat, Somaya Al-Maadeed, Abdelhamid Abdessadok   +4 more
doaj   +1 more source