Results 41 to 50 of about 75,669 (288)

Increasing digital maturity in innovative development management in a company

open access: yesВестник университета
Digital maturity level determines the ability of an enterprise to quickly and effectively implement digital management tools, including in innovative activities.
S. V. Sviridova, D. N. Horoshilov
doaj   +1 more source

Digital Transformation: Digital Maturity Model for Turkish Businesses

open access: yesGazi University Journal of Science, 2023
Changing market expectations and the increasing prevalence of the new technological trend in the world force businesses for digital transformation. However, the late realization of transformation opportunities may have devastating effects on businesses.
Merdin, Deniz   +2 more
openaire   +4 more sources

Hospitalization Through Families’ Eyes: Comparing Inpatient Care Quality for Children With Sickle Cell Disease and Cystic Fibrosis in Canada

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a chronic, inherited hemoglobinopathy that requires frequent hospitalization for disease‐related complications. Canadian data on inpatient care is limited. This study compared caregiver‐reported hospital experiences of children with SCD to those with cystic fibrosis (CF), a chronic, autosomal recessive ...
Hailey M. Zwicker   +11 more
wiley   +1 more source

Supporting Survivor‐Centered Care Through Digital Health Integration

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Survivors of childhood cancer face barriers to receiving guideline‐based, long‐term follow‐up care. Two digital tools, Passport for Care (PFC) and Cancer SurvivorLink (SurvivorLink), address complementary gaps by enabling tailored survivorship care plan (SCP) generation, updating, storage, and sharing.
Jordan G. Marchak   +15 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Digital forensic readiness : an insight into governmental and academic initiatives [PDF]

open access: yes, 2011
Digital forensics is a discipline that primarily focuses on the post-incident side of an investigation. However, during the last decade, there is a considerable amount of research that considers proactive measures taken by an organization.
Marthie Grobler   +5 more
core   +1 more source

The Role of Digital Maturity Assessment in Technology Interventions with Industrial Internet Playground

open access: yes, 2021
The use of digital technologies such as Internet of Things and advanced data analytics are central in digitally transforming manufacturing companies towards Industry 4.0.
Michail Beliatis   +5 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Digital maturity of territories during digital transformation

open access: yes, 2021
The formation of a full-fledged digital national economy integrated into a single world order is today’s trend. Under a single technological human habitat, it is necessary to understand territories as separate systemic mechanisms of the state, lined up ...
Kapkaev Yuner
core   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

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