Results 81 to 90 of about 3,337,648 (329)

Digital Maturity Assessment Model (DMAM): assimilation of Design Science Research (DSR) and Capability Maturity Model Integration (CMMI)

Digital Transformation and Society
PurposeThis study introduces the Digital Maturity Assessment Model (DMAM), a model tailored to assess the digital maturity of SMEs, tracing its development from addressing business challenges to establishing a comparative analysis framework grounded in ...
E. Omol, Lucy Waruguru Mburu, P. Abuonji
semanticscholar   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

A Framework for Managing Digital Transformation Risks in Transport Systems: Linking Digital Maturity and Risk Categories

Applied Sciences
Digital transformation is increasingly central to the development of transport systems, yet current research offers limited guidance on how digital maturity levels shape operational risk.
Agnieszka A. Tubis
doaj   +1 more source

Digitalization in the Russian healthcare: barriers to digital maturity

Population and Economics
Over the last 20 years a significant progress has been made in the use of digital technologies in the Russian healthcare: a widespread introduction of health information systems (HIS), work with big data, and use of artificial intelligence.
N. Grigorieva, A. Demkina, A. Korobeynikova   +2 more
semanticscholar   +1 more source

The Relationship Between Inflammation and Central Nervous System in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Aim Multiple sclerosis is an autoimmune demyelination disease that is seen especially in the young population and has a progressive course, causing motor, sensory, and cognitive deficits. In the literature, the pathogenesis of MS disease and the interconnection between the immune and central nervous system in the disease have not been fully ...
Gamze Ansen, Ali Behram Salar, Abdulkadir Ermis, Erkingul Birday, Lutfu Hanoglu, Bayram Ufuk Sakul   +5 more
wiley   +1 more source

D3.2 Cost Concept Model and Gateway Specification [PDF]

, 2014
This document introduces a Framework supporting the implementation of a cost concept model against which current and future cost models for curating digital assets can be benchmarked.
Ashley, Kevin, Bøgvad Kejser, Ulla, Davidson, Joy, Grindley, Neil, Hougaard Edsen Johansen, Kathrine, Krupp, Jaan, L’Hours, Hervé, McCann, Patrick, Strodl, Stephan, Thirifays, Alex, Wang, David   +10 more
core  

Summary of the First Workshop on Sustainable Software for Science: Practice and Experiences (WSSSPE1) [PDF]

, 2014
Challenges related to development, deployment, and maintenance of reusable software for science are becoming a growing concern. Many scientists’ research increasingly depends on the quality and availability of software upon which their works are built ...
Allen, Gabrielle D., Berriman, Bruce, Choi, Sou-Cheng T., Elster, Anne C., Hanwell, Marcus D., Hetherington, James, Howison, James, Katz, Daniel S., Lapp, Hilmar, Löffler, Frank, Maheshwari, Ketan, Swenson, Shel, Turk, Matthew, Venters, Colin, Wilkins-Diehr, Nancy   +14 more
core   +3 more sources

Higher Amyloid and Tau Burden Is Associated With Faster Decline on a Digital Cognitive Test

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective A 2‐min digital clock‐drawing test (DCTclock) captures more granular features of the clock‐drawing process than the pencil‐and‐paper clock‐drawing test, revealing more subtle deficits at the preclinical stage of Alzheimer's disease (AD). A previous cross‐sectional study demonstrated that worse DCTclock performance was associated with
Jessie Fanglu Fu, Talia Robinson, Marina Rodriguez Alonso, Adela Francis Malave, Roos J. Jutten, Michael J. Properzi, Brian C. Healy, Jackson C. Thompson, Grace Del Carmen Montenegro, Emma Thibault, Dana Penney, Randall Davis, Reisa A. Sperling, Kathryn V. Papp, Keith A. Johnson, Julie C. Price, Dorene M. Rentz   +16 more
wiley   +1 more source

Enterprise digital maturity: diagnostic and assessment techniquese

Ekonomika Nauki
The purpose of this article is to analyze the existing indicators of digital maturity that are used to assess the level of digital transformation in an enterprise, a group of enterprises, or sectors of the economy.
E. N. Strizhakova, D. V. Strizhakov
doaj   +1 more source

Inhibition of Classical and Alternative Complement Pathway by Ravulizumab and Eculizumab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the feasibility of classical (CH50) and alternative (AH50) complement pathway activity as potential biomarkers for treatment guidance and monitoring during therapy with ravulizumab in patients with generalized myasthenia gravis (gMG) and compare these to therapeutic drug monitoring under eculizumab.
Lea Gerischer, Frauke Stascheit, Maximilian Mönch, Paolo Doksani, Carla Dusemund, Meret Herdick, Philipp Mergenthaler, Maike Stein, Amani Suboh, Jutta Schröder‐Braunstein, Guido Wabnitz, Jan D. Lünemann, Sophie Lehnerer, Sarah Hoffmann, Andreas Meisel   +14 more
wiley   +1 more source