Results 101 to 110 of about 17,520 (245)

Research progress of electrode shapes in EWOD-based digital microfluidics. [PDF]

RSC Adv, 2023
Wu X, Tang D, He Q, Liu L, Jia Z, Tan Y.
europepmc   +1 more source

Attomolar Detection of HIV‐1 With Label‐Free RCA‐rCRISPR on Smartphone

Advanced Science, EarlyView.
A new diagnostic strategy integrating rolling circle amplification (RCA) with a plasmid reporter–based ratiometric CRISPR (rCRISPR) system was developed to detect unfragmented HIV genomes with single‐digit attomolar sensitivity. The method quantifies targets using the plasmid relaxation ratio and employs a smartphone‐based mini‐gel device to enable ...
Noor Mohammad, Anastasiia Steksova, Yuyang Tang, Leyao Huang, Alireza Velayati, Shengwei Zhang, Aditi Dey Poonam, Sina Jamalzadegan, Matthew Breen, Hongjie Chen, Mahsa Bagi, Guochun Jiang, Qingshan Wei   +12 more
wiley   +1 more source

Toward Analysis at the Point of Need: A Digital Microfluidic Approach to Processing Multi‐Source Sexual Assault Samples

Advanced Science
Forensic case samples collected in sexual assaults typically contain DNA from multiple sources, which complicates short‐tandem repeat (STR) profiling. These samples are typically sent to a laboratory to separate the DNA from sperm and non‐sperm sources ...
Mohamed Elsayed, Leticia Bodo, Christine Gaoiran, Palig Keuhnelian, Advikaa Dosajh, Vivienne Luk, Melissa Schwandt, Julie L. French, Alpana Ghosh, Barbara Erickson, Amanda G. Charlesworth, Jonathan Millman, Aaron R. Wheeler   +12 more
doaj   +1 more source

Transcription Factor Promiscuity Drives Regulatory Rewiring and Evolvability in Gene Networks in Bacteria

Advanced Science, EarlyView.
When a master transcription factor (TF) is lost, bacteria can rapidly rewire gene regulatory networks by co‐opting related regulators. Using experimental evolution in Pseudomonas fluorescens, we show that TF promiscuity (low‐level, non‐cognate binding) provides the raw material for rewiring. Successful co‐option follows a predictable hierarchy governed
Tiffany B. Taylor, Alan M. Rice
wiley   +1 more source

Polychip‐A High‐Throughput Droplet Microfluidics Platform for Interrogating Microbial Interactions

Advanced Science, EarlyView.
Polychip, a fully integrated droplet microfluidics platform, enables high‐throughput, single‐cell resolution screening of polymicrobial interactions. By seamlessly combining six automated microfluidics operations on a single chip, the system accelerates antimicrobial discovery by 11 to 14 times compared to traditional robotic methods.
Jeong Jae Han, Adrian Ryan Guzman, Aifen Zhou, Han Zhang, Rohit Gupte, Haemin Jung, Kaylee Delgado, Sini Skariah, Ali Sultan, Arul Jayaraman, Paul de Figueiredo, Arum Han   +11 more
wiley   +1 more source

Digital microfluidics-based digital counting of single-cell copy number variation (dd-scCNV Seq). [PDF]

Proc Natl Acad Sci U S A, 2023
Yu X, Ruan W, Lin F, Qian W, Zou Y, Liu Y, Su R, Niu Q, Ruan Q, Lin W, Zhu Z, Zhang H, Yang C.   +12 more
europepmc   +1 more source

Sustainable Materials Design With Multi‐Modal Artificial Intelligence

Advanced Science, EarlyView.
Critical mineral scarcity, high embodied carbon, and persistent pollution from materials processing intensify the need for sustainable materials design. This review frames the problem as multi‐objective optimization under heterogeneous, high‐dimensional evidence and highlights multi‐modal AI as an enabling pathway.
Tianyi Xu, Tianshuo Wei, Yan Ge, Bo Peng, Yue Li, Maolin Wang, Peng Wen, Chao Yang, Ye Wei   +8 more
wiley   +1 more source

Multilayered Digital Microfluidic Chip for Cell‐Based Assays

Advanced Materials Interfaces
Most conventional digital microfluidic (DMF) chips face challenges in balancing low actuation voltage, dielectric robustness, and minimal current leakage, thereby limiting their effectiveness and use for biological applications.
Mert Ozden, Oksana K. Savchak, Burcu Gumuscu   +2 more
doaj   +1 more source

Multidimensional and Multifunctional Laser‐Induced Graphene (LIG) for Point‐of‐Care and Wearable Biosensing, Theranostics, and Bioactive Interfaces Toward Personalized Healthcare and Regenerative Medicine

Advanced Science, EarlyView.
Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang, Yurou Yuan, Xiaohong Ding, Wing Cheung Mak   +3 more
wiley   +1 more source

Application of Micro/Nanoporous Fluoropolymers with Reduced Bioadhesion in Digital Microfluidics. [PDF]

Nanomaterials (Basel), 2022
Goralczyk A, Bhagwat S, Mayoussi F, Nekoonam N, Sachsenheimer K, Hou P, Kotz-Helmer F, Helmer D, Rapp BE.   +8 more
europepmc   +1 more source