Results 71 to 80 of about 4,617,744 (339)

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

open access: yesMolecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece   +18 more
wiley   +1 more source

The effects of disclosure format on native advertising recognition and audience perceptions of legacy and online news publishers [PDF]

open access: yes, 2017
This experiment with a representative sample of US adults (N=800) examines the effects of disclosure design characteristics in sponsored news on readers’ ability to recognize such content as paid advertising, and examines whether such recognition ...
Amazeen, Michelle A.   +1 more
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Social Discourse of Fake News in French and Its Digital Social Media Literacy

open access: yesLingua Cultura, 2022
The research explored the social discourse of fake news in the French language and the French government’s efforts to overcome it with digital media literacy through social media.
Merry Andriani   +2 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Exploring digital divides in older adults’ news consumption

open access: yesNordicom Review, 2020
Media structure is rapidly steering towards digital formats and distribution. Meanwhile, many Western societies have ageing populations, where older adults are less digitally active than the population at large. This, combined with the fact that the news
Bergström Annika
doaj   +1 more source

Cross-National Similarities and Differences between Legacy and Digital-Born News Media Audiences

open access: yesMedia and Communication, 2020
The decline of the news business model for print newspapers in many Western countries and the digital disruption caused by the Internet have influenced the rise of digital-born news media.
Alfonso Vara-Miguel
doaj   +1 more source

Foreign objects? Web content management systems, journalistic cultures and the ontology of software [PDF]

open access: yes, 2014
Research on ‘digital’ journalism has focused largely on online news, with comparatively less interest in the longer-term implications of software and computational technologies.
Rodgers, Scott
core   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Journalistic “Innovation” Is Hard to Hate, but Actual Change Is Just Hard

open access: yesMedia and Communication
Who is opposed to “innovation”? For most newsroom publishers, managers, editors, and reporters, the word connotes progress; it implies a strategy for achieving success—and dodging failure.
Jane B. Singer
doaj   +1 more source

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