Results 121 to 130 of about 220,110 (251)

Latent profile and associated factors of digital health literacy among patients with coronary heart disease: a cross-sectional study. [PDF]

Front Public Health
Luo L, Liao T, Gan Y, Yi M, Zou B, Lu Y, Huang Y, Liang J, Li G.   +8 more
europepmc   +1 more source

Exact Discrete Stochastic Simulation With Deep‐Learning‐Scale Gradient Optimization

Advanced Science, EarlyView.
A 203,796‐parameter gene regulatory network classifies handwritten digits with 98.4% accuracy using exact stochastic dynamics. The framework decouples forward simulation from backward differentiation, making continuous‐time Markov chain models compatible with deep‐learning optimization.
Jose M. G. Vilar, Leonor Saiz
wiley   +1 more source

The future of teaching digital public history

Geschichtswissenschaftsdidaktik
In the following text, Mills Kelly (George Mason University; currently Fulbright Scholar at the Johannes Gutenberg-University Mainz) is going to discuss the benefits and opportunities of digital public history (DPH) courses. The author is reflecting on his experience teaching DPH courses and how they offer students a wide range of career paths and ...
openaire   +1 more source

Teaching with human remains: curatorship, technological innovation and ethical engagement at the Morgagni Museum of Human Anatomy. [PDF]

Pathologica
Magno G, Zanatta A.
europepmc   +1 more source

Targeting the ATX‐LPA Axis Overcomes TKI Resistance and Immunosuppression in Renal Cell Carcinoma via Dual Inhibition of AKT/mTOR and TBK1/IRF3 Pathways

Advanced Science, EarlyView.
ABSTRACT Background Therapeutic resistance limits durable survival in advanced/metastatic renal cell carcinoma (RCC) treated with first‐line tyrosine kinase inhibitor (TKI) plus immune checkpoint inhibitor (ICI). We sought to define key resistance drivers and actionable targets.
Jinchen Luo, Hansen Lin, Haoqian Feng, Lei Tan, Xi Liu, Yong Huang, Junjie Cen, Jiajie Chen, Xinwei Zhou, Mingjie Lin, Wuyuan Liao, Zheyu Ai, Minyu Chen, Yinghan Wang, Wei Chen, Junhang Luo, Yanping Liang   +16 more
wiley   +1 more source

Gene Correction Enhances Dopaminergic Cell Therapy in a Nonhuman Primate Model of Parkinson's Disease

Advanced Science, EarlyView.
LRRK2‐mutant induced pluripotent stem cells (iPSCs) were derived from a patient with Parkinson's disease (PD). Using CRISPR/Cas9–mediated gene editing, the pathogenic LRRK2 mutations were precisely corrected, and isogenic dopaminergic neural progenitor cells (DA‐NPCs) were subsequently generated.
Qing Yan, Chongchong Xu, Jiangmei Gao, Pu Wang, Qingling Wu, Ying Jin, Binyan Lu, Mu Li, Mingting Shao, Bihai Li, Zhenghui Su, Yijng Zhang, Jianhuan Chen, Haojie An, Mengyao Huang, Xiaoji Zhuang, Yuhui Shen, Fenglin Wang, Nana Xu, Yiyan Liu, Lei Tang, Xiuling Zhong, Minyan Zhong, Jiecong Chen, Zhenhuang Wang, Xingrong Luo, Sheng Liu, RuiFeng Liu, Ling Zhang, Junhua Rao   +29 more
wiley   +1 more source

Designing interventions guided by digital phenotype and pharmacogenetics in Spain for suicidal behaviour based on retrospective data: the multicentre SMARTomicS study protocol. [PDF]

BMJ Open
Artés C, Porras-Segovia A, Ruiz-Veguilla M, Giner L, Garcia-Campayo J, López Del Hoyo Y, Alejandra-Saiz P, García-Fernández A, Martínez-Jambrina JJ, Villa-Díez R, Gili M, Roca M, de Andrés F, Pérez Sola V, Elices ME, Grande I, Cebria AI, Irigoyen-Otiñano M, Galván-Santiago L, Garcia-Iturrospe EJA, Mesones-Peral J, Mora-Marín R, Sierra P, Penas-Lledo E, LLerena A, Lopez-Castroman J, Cruz R, Arrojo M, Ovejero S, de la Torre-Luque A, Palao-Tarrero Á, Vaquero-Lorenzo C, Toma C, Barrigon ML, Artes A, Díaz-Marsá M, Ayad-Ahmed W, Ibáñez Á, Díaz-Sastre C, Salvador-Robert M, Álvarez-García R, Mata-Iturralde L, Benavente-López S, Muñoz-Lorenzo L, Di Stasio EF, Carmona-Camacho R, Peñuelas-Calvo I, Valencia M, López Peña P, Albarracín-García L, Baca-Garcia E.   +50 more
europepmc   +1 more source

Multi‐tissue Metabolic GWAS and Drought‐Responsive Multi‐omics Reveal the Genetic Basis of the Quinoa Metabolome

Advanced Science, EarlyView.
A multi‐omics framework combining multitissue genome‐wide association studies, metabolomics, transcriptomics, proteomics, and functional validation uncovers the genetic basis of specialized metabolism in quinoa. The study identifies hundreds of metabolite‐associated loci, prioritizes candidate genes for saponin, betalain, and flavonoid biosynthesis ...
Julia von Steimker, Elodie L. Rey, Clara Stanschewski, Regina Wendenburg, Annabella Klemmer, Markéta Macho, Venkatesh P. Thirumalaikumar, Noha O. Saber, Aleksandra Skirycz, Alisdair R. Fernie, Mark Tester, Saleh Alseekh   +11 more
wiley   +1 more source

Lessons from a 'low-tech' community approach to youth mental health in Argentina: shared space, purpose and stories. [PDF]

Lancet Reg Health Am
Buedo P, Daly T.
europepmc   +1 more source

Automating Chemical Reasoning in High‐Throughput Phase Identification With a Probabilistic, LLM‐Guided Framework

Advanced Science, EarlyView.
Autonomous laboratories can now synthesize materials faster than experts can interpret the resulting diffraction data. A probabilistic framework combines refinement‐fit metrics with large language model‐derived chemical reasoning to rank competing phase interpretations and flag those unsuitable for autonomous use.
Olympia Dartsi, Lauren N. Walters, Amalie E. Trewartha, Steven B. Torrisi, Amanda Volk, Liam Joyce, Gerbrand Ceder, Anubhav Jain   +7 more
wiley   +1 more source