Results 31 to 40 of about 220,110 (251)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Distant reading televised public information: The communication of Swedish government agencies, 1978- 2020

NECSUS, 2022
This study focuses on the Swedish public information programme Anslagstavlan, a unique audiovisual communication tool for Swedish government agencies since 1972 and an important part of Sweden’s audiovisual cultural heritage.
Emil Stjernholm
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Commemoration of an Epoch: Monuments to the Women’s Suffrage Movement in the United States

Panorama, 2022
This data-driven analysis unearths monuments that have received little attention, reveals an evolving narrative of the public commemoration of women, and demonstrates how the methods of the digital humanities can enhance the study of art.
Sierra Rooney
doaj   +1 more source

Risk-Generating aspect of public history in digital environment (on the example of Russian video blogging in the 2020s)

Цифровая социология, 2023
The article contains materials of a sociological study of public history sociocultural practices in social media. Based on the analysis of data from in-depth interviews with experts in the field of media history (N = 60) conducted in 2022-2023, a ...
Yu. V. Nikulich
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Alcune riflessioni sui rapporti tra la memoria dei campi di concentramento fascisti e le nuove forme digitali di divulgazione storica

Diacronie. Studi di Storia Contemporanea, 2018
The article offers some reflections on the relationship between the memory of the fascist concentration camps and the new digital forms of historical popularization and outreaching, introducing and locating within current scholarship trends the ...
Carlo Spartaco CAPOGRECO è noto a livello internazionale per il fondamentale contributo dato alla riscoperta dell’internamento civile fascista. Tra i suoi scritti ricordiamo: Ferramonti. La vita e gli uomini del più grande campo d’internamento fascista (Firenze, La Giuntina 1987); I campi del duce (Torino, Einaudi 2004), edito anche nelle lingue croata (Zagreb, Golden marketing, 2006), slovena (Ljubljana, Publicistično društvo ZAK, 2011) ed inglese (London-New York, Routledge, in corso di pubblicazione); Il piombo e l’argento (Roma, Donzelli, 2007). Ha collaborato al Dizionario della Resistenza, al Dizionario del fascismo e al Dizionario dell’Olocausto, editi da Einaudi; alla Storia della Shoah in Italia (edita da Utet) ed alla Encyclopedia of Camps and Ghettos (edita dall’U.S. Holocaust Memorial Museum).
doaj