Results 61 to 70 of about 10,060,996 (327)
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Young adults not in education, employment, or training (NEET): a global scoping review
BMC Public HealthBackground Young adults not in education, employment, or training (NEET) represent a significant global issue, with varying challenges across different countries.
Mari Gunnes +4 more
doaj +1 more source
The Dynamics of Transformation in the Development of Digital Services [PDF]
, 2018 Service providers are increasingly depending and using digital infrastructure and tools provided by digital platforms to transform their services and develop digital ones that meet the needs of heterogeneous end users. However, while there is an emerging
Ghazawneh, Ahmad
core +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
The Industry and Policy Context for Digital Games for Empowerment and Inclusion:Market Analysis, Future Prospects and Key Challenges in Videogames, Serious Games and Gamification [PDF]
, 2013 The effective use of digital games for empowerment and social inclusion (DGEI) of people and communities at risk of exclusion will be shaped by, and may influence the development of a range of sectors that supply products, services, technology and ...
Misuraca, Gianluca, Stewart, James
core +1 more source
The International Journal of Life Cycle Assessment, 2020 The substitution of material-based services with digital services—for example films or music—alters the environmental impact of our everyday activities and shifts visible material use to less visible digital services.
R. Itten +11 more
semanticscholar +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Using assurance frameworks to manage the risks and uncertainties of an energy sector digital spine
IET Smart GridThe energy transition requires a profound transformation of the entire energy system. The adoption of diverse, distributed renewable energy sources into the energy mix requires many assets, actions, stakeholders, and decisions to communicate with each ...
Henry James Thraves +4 more
doaj +1 more source
Applied Sciences, 2023 Centrifugal pumps are widely employed in the oil refinery industry due to their efficiency and effectiveness in fluid transfer applications. The reliability of pumps plays a pivotal role in ensuring uninterrupted plant productivity and safe operations ...
José Silva +3 more
doaj +1 more source