Results 61 to 70 of about 10,557,116 (346)

A distributed alerting service for open digital library software [PDF]

, 2005
Alerting for Digital Libraries (DL) is an important and useful feature for the library users. To date, two independent services and a few publisher-hosted proprietary services have been developed.
Buchanan, George, Hinze, Annika
core   +2 more sources

Acceptability of artificial intelligence (AI)-enabled chatbots, video consultations and live webchats as online platforms for sexual health advice [PDF]

, 2020
Objectives Sexual and reproductive health (SRH) services are undergoing a digital transformation. This study explored the acceptability of three digital services, (i) video consultations via Skype, (ii) live webchats with a health advisor and (iii ...
Bayley, J., Bayley, J., Graham, C.A., Graham, C.A., Kidsley, S., Kidsley, S., Llewellyn, C., Llewellyn, C., Nadarzynski, T., Nadarzynski, T.   +9 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Young adults not in education, employment, or training (NEET): a global scoping review

BMC Public Health
Background Young adults not in education, employment, or training (NEET) represent a significant global issue, with varying challenges across different countries.
Mari Gunnes, Kristin Thaulow, Silje L. Kaspersen, Chris Jensen, Solveig Osborg Ose   +4 more
doaj   +1 more source

Multi-Head Attention Deep Q-Network with Prioritized Experience Replay for UAV Path Planning in Dynamic Environments: A Bio-Inspired Approach

Biomimetics
Unmanned Aerial Vehicles (UAVs) have become widely used tools for different applications including surveillance, search and rescue, and package delivery.
Yang Li, Xinjie Qian, Jiexin Zhang, Xiao Yang, Chao Deng   +4 more
doaj   +1 more source

Using Smart Traffic Lights to Reduce CO₂ Emissions and Improve Traffic Flow at Intersections: Simulation of an Intersection in a Small Portuguese City

Applied System Innovation, 2023
Reducing CO2 emissions is currently a key policy in most developed countries. In this article, we evaluate whether smart traffic lights can have a relevant role in reducing CO2 emissions in small cities, considering their specific traffic profiles.
Osvaldo Santos, Fernando Ribeiro, José Metrôlho, Rogério Dionísio   +3 more
doaj   +1 more source

The Dynamics of Transformation in the Development of Digital Services [PDF]

, 2018
Service providers are increasingly depending and using digital infrastructure and tools provided by digital platforms to transform their services and develop digital ones that meet the needs of heterogeneous end users. However, while there is an emerging
Ghazawneh, Ahmad
core   +1 more source

Digital reference services : a snapshot of the current practices in scottish libraries [PDF]

, 2004
Discusses the current practices followed by some major libraries in Scotland for providing digital reference services(DRS). Refers to the DRSs provided by three academic libraries, namely Glasgow University Library, the University of Strathclyde Library,
Chowdhury, G., Margariti, S.
core   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source