Results 31 to 40 of about 1,150,767 (291)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
The role of telecommunications operators on smart home service platforms [PDF]
, 2014 The formation and evolution of digital service platforms is changing the balance of powers in the ICT industry. In particular, telecommunications operators feel the need to gain more control over the creation and provision of new services and to revise ...
Kuebel, Hannes, Zarnekow, Ruediger
core
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
European Journal of Risk RegulationThis article examines the systemic risk management regimes introduced by the Digital Services Act (DSA) and the Artificial Intelligence Act (AI Act) through the lens of EU constitutional law.
Andrea Palumbo
doaj +1 more source
How the web continues to fail people with disabilities [PDF]
, 2008 The digital divide is most often understood as that between the IT haves and have-nots. However, if there is one minority group that can be, and often is excluded from the world wide web, even if they have a computer, it is disabled people.
Kreps, David
core
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
From AT&T to Brand X Declining Checks and Balances in an Increasingly Complex Marketplace [PDF]
, 2006 When President Clinton signed the Telecommunications Act of 1996, he used the same pen that President Eisenhower used to sign legislation for the Interstate Highway system into law. It was a fitting analogy.
Hicks, Ross G.
core +1 more source
Revisiting network neutrality [PDF]
, 2008 The paper discusses the topical subject of network neutrality, from a US and European legal perspective. The article will begin by first defining network neutrality before addressing the underpinning technology and will then compare the legal approaches ...
Garrie, DB, Loewenherz, DW, Wong, R
core +1 more source
PRECEPT:a framework for ethical digital forensics investigations [PDF]
, 2020 Purpose: Cyber-enabled crimes are on the increase, and law enforcement has had to expand many of their detecting activities into the digital domain. As such, the field of digital forensics has become far more sophisticated over the years and is now able ...
Ferguson, R.I. +3 more
core +5 more sources
Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler +20 more
wiley +1 more source