Results 41 to 50 of about 898,390 (352)

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

An Adaptive Source-Channel Coding with Feedback for Progressive Transmission of Medical Images

International Journal of Telemedicine and Applications, 2009
A novel adaptive source-channel coding with feedback for progressive transmission of medical images is proposed here. In the source coding part, the transmission starts from the region of interest (RoI).
Jen-Lung Lo, Saeid Sanei, Kianoush Nazarpour   +2 more
doaj   +1 more source

Validation of IMU-based gait event detection during curved walking and turning in older adults and Parkinson’s Disease patients

Journal of NeuroEngineering and Rehabilitation, 2021
Background Identification of individual gait events is essential for clinical gait analysis, because it can be used for diagnostic purposes or tracking disease progression in neurological diseases such as Parkinson’s disease.
Robbin Romijnders, Elke Warmerdam, Clint Hansen, Julius Welzel, Gerhard Schmidt, Walter Maetzler   +5 more
doaj   +1 more source

Processing Chain for Localization of Magnetoelectric Sensors in Real Time

Sensors, 2021
The knowledge of the exact position and orientation of a sensor with respect to a source (distribution) is essential for the correct solution of inverse problems.
Christin Bald, Gerhard Schmidt
doaj   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

An Event Recognition Method for Φ-OTDR Sensing System Based on Deep Learning

Sensors, 2019
Phase-sensitive optical time domain reflectometer (Φ-OTDR) based distributed optical fiber sensing system has been widely used in many fields such as long range pipeline pre-warning, perimeter security and structure health monitoring.
Yi Shi, Yuanye Wang, Lei Zhao, Zhun Fan
doaj   +1 more source

Digital Signal Processing [PDF]

, 1987
Contains an introduction and reports on twenty research projects.National Science Foundation (Grant ECS 84-07285)U.S. Navy - Office of Naval Research (Contract N00014-81-K-0742)National Science Foundation FellowshipSanders Associates, Inc.U.S. Air Force -
Bondaryk, Joseph E., Cobra, Daniel T., Covell, Michele M., Davis, Randall, Dove, Webster P., Feder, Meir, Frisk, George V., Griffin, Daniel W., Harasty, Daniel J., Hardwick, John C., Izraelevitz, David, Jachner, Jacek, Joo, Tae H., Lim, Jae S., Martinez, Dennis M., Milios, Evangelos E., Myers, Cory S., Oppenheim, Alan V., Pappas, Thrasyvoulos N., Rodriguez, Jeffrey J., Silva, Anthony J., van Hove, Patrick, Weinstein, Ehud, Wengrovitz, Michael S., Zakhor, Avideh   +24 more
core  

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

Molecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens   +17 more
wiley   +1 more source

Digital Signal Processing [PDF]

, 1973
Contains reports on one research project.U. S.
Oppenheim, Alan V., Tribolet, J. M.
core  

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source